Results 291 to 300 of about 4,753,986 (376)

PANTHER-PSEP: predicting disease-causing genetic variants using position-specific evolutionary preservation

Bioinform., 2016
Haiming Tang, P. Thomas
semanticscholar   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

The Impact of Smoking-Associated Genetic Variants on Post-Exercise Heart Rate. [PDF]

Int J Mol Sci
Al Ashkar H, Kharrat Helu N, Kovacs N, Fiatal S, Adany R, Piko P.   +5 more
europepmc   +1 more source

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.

Journal of the American Medical Association (JAMA), 2016
L. Lotta, S. Sharp, S. Burgess, J. Perry, I. Stewart, Sara M. Willems, J. Luan, E. Ardanaz, L. Arrióla, B. Balkau, H. Boeing, P. Deloukas, N. Forouhi, P. Franks, S. Grioni, R. Kaaks, T. Key, C. Navarro, P. Nilsson, K. Overvad, D. Palli, S. Panico, J. Quirós, E. Riboli, O. Rolandsson, C. Sacerdote, Elena C Salamanca, N. Slimani, A. Spijkerman, A. Tjønneland, R. Tumino, D. van der A, Y. T. van der Schouw, M. McCarthy, I. Barroso, S. O’Rahilly, D. Savage, N. Sattar, C. Langenberg, R. Scott, N. Wareham   +40 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Genetic Variant Coding for Iron Regulatory Protein HFE Contributes to Hypertension, the TAMRISK Study

, 2015
Kirsi Määttä, Seppo T. Nikkari, Tarja Kunnas   +2 more
openalex   +1 more source

Combinatorial interactions of genetic variants in human cardiomyopathy

Nature Biomedical Engineering, 2019
Dekker C. Deacon, C. Happe, Chao Chen, Neil Tedeschi, A. M. Manso, Ting Li, N. Dalton, Qian Peng, Elie N. Farah, Yusu Gu, Kevin P. Tenerelli, Vivien D. Tran, Ju Chen, K. Peterson, N. Schork, E. Adler, A. Engler, R. Ross, N. Chi   +18 more
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Genetic Variants in the ATF6 Gene and Their Relationship with Milk-Quality Traits in Yaks. [PDF]

Animals (Basel)
Ma X, Guo X, La Y, Wu X, Chu M, Bao P, Yan P, Liang C.   +7 more
europepmc   +1 more source