Results 301 to 310 of about 4,753,986 (376)

Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction

Journal of the American Medical Association (JAMA), 2017
S. Larsson, S. Burgess, K. Michaëlsson
semanticscholar   +1 more source

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

Association of Inherited Genetic Variants with Multiple Primary Melanoma. [PDF]

Cancer Epidemiol Biomarkers Prev
Gibbs DC, Small BM, Autuori I, Leong SF, Ali E, Kenney J, Luo L, Kanetsky PA, Busam KJ, Cust AE, Anton-Culver H, Gallagher RP, Zanetti R, Rosso S, Sacchetto L, Edmiston SN, Conway K, Ollila DW, Begg CB, Berwick M, Orlow I, Thomas NE, GEM Study Group.   +22 more
europepmc   +1 more source

Genetic Variant Of TGF-ß Associated with Decline Renal Function in Type II Diabetes Mellitus Patient; Single Center Pilot Study in Indonesia

, 2021
Anggelia Puspasari
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Common genetic variants modify disease risk and clinical presentation in monogenic diabetes. [PDF]

Nat Metab
Murray Leech J, Beaumont RN, Arni AM, Chundru VK, Sharp LN, Colclough K, Hattersley AT, Weedon MN, Patel KA.   +8 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Commentary: Complement genetic variants and FH desialylation in <i>S. pneumoniae</i>-haemolytic uraemic syndrome. [PDF]

Front Immunol
Baas LM, van de Kar NCAJ, Michels MAHM, van den Heuvel LP.   +3 more
europepmc   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Interplay of the Genetic Variants and Allele Specific Methylation in the Context of a Single Human Genome Study. [PDF]

Int J Mol Sci
Voronina MD, Zayakina OV, Deinichenko KA, Shingalieva OS, Tsimmer OY, Tarasova DA, Grebnev PA, Snigir EA, Mitrofanov SI, Yudin VS, Keskinov AA, Yudin SM, Svetlichnyy DV, Skvortsova VI.   +13 more
europepmc   +1 more source