Results 311 to 320 of about 4,753,986 (376)

Weighted burden analysis of rare genetic variants identifies novel genes with effects on BMI [PDF]

David Curtis
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Non-coding genetic variants underlying higher prostate cancer risk in men of African ancestry. [PDF]

Nat Commun
Li S, Fatema K, Sundarraj N, Singh A, Rajagopal PS, Notani D, Takeda DY, Hannenhalli S.   +7 more
europepmc   +1 more source

Genetic Variants of Vitiligo

Clinical Dermatology Open Access Journal, 2018
openaire   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Leveraging underrepresented population data improves interpretation of genetic variants associated with hearing loss. [PDF]

Sci Rep
Joo SY, Jang SH, Kim JA, Kim SJ, Choi JY, Jung J, Gee HY.   +6 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Genetic variants associated with gout identified through a genome-wide study in the UK biobank (N = 150 542). [PDF]

Hum Mol Genet
Tao Y, Cai T, Pan Q, Yang L, Lin S, Haque M, Dottorini T, Abhishek A, Meng W.   +8 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Genetic Variants Associated With Neurodegenerative Disorders in Patients With Amyotrophic Lateral Sclerosis and Phenotypic Variability. [PDF]

Neurology
Grassano M, Koumantakis E, Palumbo FF, Brunetti M, De Marco G, Merulla I, Paolantonio C, Iazzolino B, Testa M, Manera U, Canosa A, Vasta R, Fuda G, Salamone P, Marchese G, Casale F, Gallone S, Mora G, Moglia C, Calvo A, Chiò A.   +20 more
europepmc   +1 more source