Results 311 to 320 of about 4,570,575 (370)

Association of SLCO1B1 genetic variants with neonatal hyperbilirubinemia: a consolidated analysis of 36 studies. [PDF]

BMC Pediatr
Talebi H, Dastgheib SA, Vafapour M, Bahrami R, Shahbazi A, Shams SE, Danaei M, Rashnavadi H, Yeganegi M, Pourkazemi M, Shiri A, Aghasipour M, Neamatzadeh H.   +12 more
europepmc   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Genetic variants and phenotypic data curated for the CAGI6 intellectual disability panel challenge. [PDF]

Hum Genet
Aspromonte MC, Del Conte A, Polli R, Baldo D, Benedicenti F, Bettella E, Bigoni S, Boni S, Ciaccio C, D'Arrigo S, Donati I, Granocchio E, Mammi I, Milani D, Negrin S, Nosadini M, Soli F, Stanzial F, Turolla L, Piovesan D, Tosatto SCE, Murgia A, Leonardi E.   +22 more
europepmc   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Protocol for the functional evaluation of genetic variants using saturation genome editing. [PDF]

STAR Protoc
Obolenski S, Olvera-León R, Sun D, Adams DJ, Waters AJ.   +4 more
europepmc   +1 more source

Allelic frequencies of host genetic variants influencing susceptibility to HIV-1 infection and disease in South African populations

, 2000
Carolyn Williamson, Shayne Loubser, Belinda Brice, G Joubert, Teresa Smit, R. Klei Thomas, Melanie Visagie, Mark E. Cooper, Elna van der Ryst   +8 more
openalex   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

Genetic variants and molecular profiling of 46,XY gonadal dysgenesis using whole-exome sequencing. [PDF]

Front Endocrinol (Lausanne)
Zhang N, You S, Guo J, Chang X, Qiu J, Hua K.   +5 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Detection of Genetic Variants in Thai Population by Trio-Based Whole-Genome Sequencing Study. [PDF]

Biology (Basel)
Boonin P, Klumsathian S, Iemwimangsa N, Sensorn I, Charoenyingwatana A, Chantratita W, Chareonsirisuthigul T.   +6 more
europepmc   +1 more source