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Genetic Variation of PPARs [PDF]
PPAR Research, 2009 Welcome to this special issue of PPAR Research dedicated to the “Genetic Variation of PPARs.” Since PPARs are nuclear transcription factors regulating multiple genes involved in energy production, glucose and lipid metabolism, polymorphisms in these receptors may influence the pathology of numerous diseases including obesity, diabetes, atherosclerosis,
Marie-Claude Vohl +2 more
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Estimated six per cent loss of genetic variation in wild populations since the industrial revolution
Evolutionary Applications, 2019 Genetic variation is fundamental to population fitness and adaptation to environmental change. Human activities are driving declines in many wild populations and could have similar effects on genetic variation.
Deborah M. Leigh +3 more
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Population Genetics with R, 2020 An introduction to randomness and the neutral theory of molecular evolution and how it contributes to levels of genetic diversity in populations. The estimation of random shifts in allele frequencies over time is discussed using the binomial probability ...
Á. J. Láruson, F. A. Reed
semanticscholar +3 more sources
Population genomics reveal distinct and diverging populations of An. minimus in Cambodia
Communications Biology, 2022 Using whole genome sequencing and broad sampling across the nation, the genetic diversity of the malaria mosquito An. minimus across Cambodia is described.
Brandyce St. Laurent +13 more
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Asian Journal of Pharmaceutical Sciences, 2022 Extracellular vesicles (EVs)-based cell-free therapy, particularly stem cell-derived extracellular vesicles (SC-EVs), offers new insights into treating a series of neurological disorders and becomes a promising candidate for alternative stem cell ...
Shilin Jin +7 more
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Scientific Reports, 2022 Populations in seasonal fluctuating environments receive multiple environmental cues and must deal with this heterogenic environment to survive and reproduce.
Banu Şebnem Önder, Cansu Fidan Aksoy
doaj +1 more source
Genetic Variation and Atherosclerosis [PDF]
Current Genomics, 2008 A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk ...
Biros, Erik +2 more
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TLR7 gain-of-function genetic variation causes human lupus
Nature, 2022 Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease1–7, evidence of lupus-causing TLR7 gene variants is lacking. Here we describe human systemic lupus erythematosus
G. Brown +43 more
semanticscholar +1 more source
The crucial role of genome-wide genetic variation in conservation
Proceedings of the National Academy of Sciences of the United States of America, 2021 The unprecedented rate of extinction calls for efficient use of genetics to help conserve biodiversity. Several recent genomic and simulation-based studies have argued that the field of conservation biology has placed too much focus on conserving genome ...
Marty Kardos +7 more
semanticscholar +1 more source
Cryptic genetic variation [PDF]
Current Biology, 2008 What is cryptic genetic variation? Cryptic genetic variation refers to unexpressed, bottled-up genetic potential. It is not normally seen, but is expressed under abnormal conditions such as in a new environment or a different genetic background.
Gibson Greg, Reed, Laura K.
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