Results 1 to 10 of about 8,139,164 (377)

Estimated six per cent loss of genetic variation in wild populations since the industrial revolution

Evolutionary Applications, 2019
Genetic variation is fundamental to population fitness and adaptation to environmental change. Human activities are driving declines in many wild populations and could have similar effects on genetic variation.
Deborah M. Leigh, Andrew P. Hendry, Ella Vázquez‐Domínguez, Vicki L. Friesen   +3 more
doaj   +2 more sources

Population genomics reveal distinct and diverging populations of An. minimus in Cambodia

Communications Biology, 2022
Using whole genome sequencing and broad sampling across the nation, the genetic diversity of the malaria mosquito An. minimus across Cambodia is described.
Brandyce St. Laurent, Nick Harding, Nick Deason, Kolthida Oy, Chea Sok Loeun, Men Sary, Rous Sunly, Sen Nhep, Eleanor Drury, Kirk Rockett, Siv Sovannaroth, Sonia Goncalves, Dominic Kwiatkowski, Alistair Miles   +13 more
doaj   +1 more source

Next generation of neurological therapeutics: Native and bioengineered extracellular vesicles derived from stem cells

Asian Journal of Pharmaceutical Sciences, 2022
Extracellular vesicles (EVs)-based cell-free therapy, particularly stem cell-derived extracellular vesicles (SC-EVs), offers new insights into treating a series of neurological disorders and becomes a promising candidate for alternative stem cell ...
Shilin Jin, Zhongyue Lv, Lin Kang, Jiayi Wang, Chengcheng Tan, Liming Shen, Liang Wang, Jing Liu   +7 more
doaj   +1 more source

TLR7 gain-of-function genetic variation causes human lupus

Nature, 2022
Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease1–7, evidence of lupus-causing TLR7 gene variants is lacking. Here we describe human systemic lupus erythematosus
G. Brown, Pablo F Cañete, Hao Wang, Arti Medhavy, J. Bones, Jonathan A. Roco, Yuke He, Y. Qin, J. Cappello, J. Ellyard, Katharine Bassett, Q. Shen, G. Burgio, Yaoyuan Zhang, C. Turnbull, Xian-Ce Meng, Philip Wu, Eun Cho, L. Miosge, T. Andrews, Matt A. Field, D. Tvorogov, A. Lopez, J. Babon, C. A. López, Á. Gónzalez-Murillo, D. C. Garulo, V. Pascual, T. Levy, E. Mallack, D. Calame, T. Lotze, J. Lupski, Huihua Ding, Tomalika R. Ullah, G. Walters, M. Koina, M. Cook, N. Shen, C. de Lucas Collantes, B. Corry, M. Gantier, V. Athanasopoulos, C. Vinuesa   +43 more
semanticscholar   +1 more source

Seasonal variation in wing size and shape of Drosophila melanogaster reveals rapid adaptation to environmental changes

Scientific Reports, 2022
Populations in seasonal fluctuating environments receive multiple environmental cues and must deal with this heterogenic environment to survive and reproduce.
Banu Şebnem Önder, Cansu Fidan Aksoy
doaj   +1 more source

The crucial role of genome-wide genetic variation in conservation

Proceedings of the National Academy of Sciences of the United States of America, 2021
The unprecedented rate of extinction calls for efficient use of genetics to help conserve biodiversity. Several recent genomic and simulation-based studies have argued that the field of conservation biology has placed too much focus on conserving genome ...
Marty Kardos, E. Armstrong, S. Fitzpatrick, Samantha S Hauser, P. Hedrick, Joshua M. Miller, David A. Tallmon, W. Funk   +7 more
semanticscholar   +1 more source

A complete reference genome improves analysis of human genetic variation

bioRxiv, 2021
Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200 Mbp of sequence, corrects thousands of structural errors, and unlocks the most complex regions of the human genome to clinical and functional study.
S. Aganezov, Stephanie M. Yan, Daniela C. Soto, Melanie Kirsche, Samantha Zarate, P. Avdeyev, Dylan J. Taylor, Kishwar Shafin, Alaina Shumate, Chunlin Xiao, Justin Wagner, Jennifer McDaniel, Nathan D. Olson, M. Sauria, Mitchell R. Vollger, A. Rhie, Melissa Meredith, S. Martin, Joyce Lee, S. Koren, J. Rosenfeld, B. Paten, Ryan M. Layer, Chen-Shan Chin, F. Sedlazeck, Nancy F. Hansen, Danny E. Miller, A. Phillippy, K. Miga, R. McCoy, M. Dennis, J. Zook, M. Schatz   +32 more
semanticscholar   +1 more source

Inter‐ and intraspecific variation in mycotoxin tolerance: A study of four Drosophila species

Ecology and Evolution, 2022
Many mycophagous Drosophila species have adapted to tolerate high concentrations of mycotoxins, an ability not reported in any other eukaryotes. Although an association between mycophagy and mycotoxin tolerance has been established in many Drosophila ...
Prajakta P. Kokate, Morgan Smith, Lucinda Hall, Kui Zhang, Thomas Werner   +4 more
doaj   +1 more source

Genetic diversity and structure of the Norway spruce Picea abies (L.) H. Karst. seed orchards of the first and the second order in Belarus [PDF]

Сибирский лесной журнал, 2020
The genetic diversity of 5 seed orchards of the first (I) and 12 the second (II) orders of the Norway spruce Picea abies (L.) H. Karst. was analyzed on basis of the isoenzyme analysis method, was carried the study with 18 isoenzyme genes.
S. I. Ivanovskaya, D. I. Kagan, V. E. Padutov   +2 more
doaj   +1 more source

Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan in Drosophila melanogaster

Frontiers in Genetics, 2020
Most eukaryotic genes express multiple transcripts and proteins, and a sophisticated gene expression strategy plays a crucial role in ensuring the cell-specificity of genetic information and the correctness of phenotypes. The Drosophila melanogaster gene
Mikhail V. Trostnikov, Ekaterina R. Veselkina, Anna V. Krementsova, Anna V. Krementsova, Stepan V. Boldyrev, Stepan V. Boldyrev, Natalia V. Roshina, Natalia V. Roshina, Elena G. Pasyukova   +8 more
doaj   +1 more source