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Genetic Variation of PPARs [PDF]
PPAR Research, 2009 Welcome to this special issue of PPAR Research dedicated to the “Genetic Variation of PPARs.” Since PPARs are nuclear transcription factors regulating multiple genes involved in energy production, glucose and lipid metabolism, polymorphisms in these receptors may influence the pathology of numerous diseases including obesity, diabetes, atherosclerosis,
Marie-Claude Vohl +2 more
doaj +4 more sources
Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits [PDF]
arXiv, 2010 Non-genetic perturbations, such as environmental change or developmental noise, can induce novel phenotypes. If an induced phenotype confers a fitness advantage, selection may promote its genetic stabilization. Non-genetic perturbations can thus initiate evolutionary innovation.
Ancel +73 more
arxiv +5 more sources
A global reference for human genetic variation [PDF]
Nature, 2015 The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage ...
Taras K. Oleksyk +76 more
semanticscholar +18 more sources
Estimated six per cent loss of genetic variation in wild populations since the industrial revolution
Evolutionary Applications, 2019 Genetic variation is fundamental to population fitness and adaptation to environmental change. Human activities are driving declines in many wild populations and could have similar effects on genetic variation.
Deborah M. Leigh +3 more
doaj +2 more sources
Genetic variation in healthy oldest-old. [PDF]
PLoS ONE, 2009 Individuals who live to 85 and beyond without developing major age-related diseases may achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance factors that enhance their ability to avoid disease and prolong lifespan.
Julius Halaschek-Wiener +16 more
doaj +7 more sources
Population genomics reveal distinct and diverging populations of An. minimus in Cambodia
Communications Biology, 2022 Using whole genome sequencing and broad sampling across the nation, the genetic diversity of the malaria mosquito An. minimus across Cambodia is described.
Brandyce St. Laurent +13 more
doaj +1 more source
Scientific Reports, 2022 Populations in seasonal fluctuating environments receive multiple environmental cues and must deal with this heterogenic environment to survive and reproduce.
Banu Şebnem Önder, Cansu Fidan Aksoy
doaj +1 more source
The crucial role of genome-wide genetic variation in conservation
Proceedings of the National Academy of Sciences of the United States of America, 2021 The unprecedented rate of extinction calls for efficient use of genetics to help conserve biodiversity. Several recent genomic and simulation-based studies have argued that the field of conservation biology has placed too much focus on conserving genome ...
Marty Kardos +7 more
semanticscholar +1 more source
Genetic Variation and Atherosclerosis [PDF]
Current Genomics, 2008 A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk ...
Biros, Erik +2 more
openaire +4 more sources
Cryptic genetic variation [PDF]
Current Biology, 2008 What is cryptic genetic variation? Cryptic genetic variation refers to unexpressed, bottled-up genetic potential. It is not normally seen, but is expressed under abnormal conditions such as in a new environment or a different genetic background.
Gibson Greg, Reed, Laura K.
openaire +4 more sources