Results 1 to 10 of about 4,837,445 (261)

Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma

open access: yesFrontiers in Genetics, 2013
Increasing evidence suggests that single nucleotide polymorphisms (SNPs) associated with complex traits are more likely to be expression quantitative trait loci (eQTLs).
Lin eLi   +10 more
doaj   +1 more source

Network-assisted analysis of GWAS data identifies a functionally-relevant gene module for childhood-onset asthma

open access: yesScientific Reports, 2017
The number of genetic factors associated with asthma remains limited. To identify new genes with an undetected individual effect but collectively influencing asthma risk, we conducted a network-assisted analysis that integrates outcomes of genome-wide ...
Y. Liu   +11 more
doaj   +1 more source

Reduced Neuronal Transcription of Escargot, the Drosophila Gene Encoding a Snail-Type Transcription Factor, Promotes Longevity

open access: yesFrontiers in Genetics, 2018
In recent years, several genes involved in complex neuron specification networks have been shown to control life span. However, information on these genes is scattered, and studies to discover new neuronal genes and gene cascades contributing to life ...
Alexander V. Symonenko   +5 more
doaj   +1 more source

Wild worm embryogenesis harbors ubiquitous polygenic modifier variation

open access: yeseLife, 2015
Embryogenesis is an essential and stereotypic process that nevertheless evolves among species. Its essentiality may favor the accumulation of cryptic genetic variation (CGV) that has no effect in the wild-type but that enhances or suppresses the effects ...
Annalise B Paaby   +5 more
doaj   +1 more source

Genetic variability for vigor and yield of robusta coffee (Coffea canephora) clones in Ghana

open access: yesHeliyon, 2022
Effectiveness of plant improvement programs, especially in perennial crops like coffee, may be improved by knowing the level of genetic variation which exist within a breeding population coupled with the knowledge of estimates of genetic parameters for ...
Abraham Akpertey   +3 more
doaj   +1 more source

Genetics of trans-regulatory variation in gene expression

open access: yeseLife, 2018
Heritable variation in gene expression forms a crucial bridge between genomic variation and the biology of many traits. However, most expression quantitative trait loci (eQTLs) remain unidentified.
Frank Wolfgang Albert   +4 more
doaj   +1 more source

Impact of pharmacogenetics on aspirin resistance: a systematic review

open access: yesArquivos de Neuro-Psiquiatria, 2023
Background Pharmacogenetics promises better control of diseases such as cardiovascular disease (CVD). Acetylsalicylic acid, aspirin, prevents the formation of an activating agent of platelet aggregation and vasoconstriction, and it is used to prevent CVD.
Gustavo Figueiredo da Silva   +3 more
doaj   +1 more source

Assessment of Genetic Diversity and Conservation in South African Indigenous Goat Ecotypes: A Review

open access: yesAnimals, 2022
Goats were amongst the first livestock to be domesticated more than 10,000 years ago for their meat, milk, skin, and fiber. They were introduced to Southern Africa by migrating nations from Central Africa to the south.
Aletta Matshidiso Magoro   +3 more
doaj   +1 more source

Oracle selection provides insight into how far off practice is from Utopia in plant breeding

open access: yesFrontiers in Plant Science, 2023
Since the introduction of genomic selection in plant breeding, high genetic gains have been realized in different plant breeding programs. Various methods based on genomic estimated breeding values (GEBVs) for selecting parental lines that maximize the ...
David Vanavermaete   +3 more
doaj   +1 more source

Genetic variation and population structure of the mushroom Pleurotus ferulae in China inferred from nuclear DNA analysis

open access: yesJournal of Integrative Agriculture, 2016
To investigate the genetic diversity of an edible fungus Pleurotus ferulae, a total of 89 wild samples collected from six geographical locations in the Xinjiang Uygur Autonomous Region of China and two geographical locations in Italy, were analyzed using
Meng-ran ZHAO   +7 more
doaj   +1 more source

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