Results 281 to 290 of about 6,167,941 (317)
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Annual Review of Genetics, 1995
Life span is subject to genetic modification in yeasts, nematodes, fruit flies, mice, humans, and other vertebrates and invertebrates. There are a few single-gene mutants known that extend life span in yeast and nematodes; in other experimental systems the character is treated quantitatively, and generally has a low to moderate heritability.
Marc Tatar +6 more
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Life span is subject to genetic modification in yeasts, nematodes, fruit flies, mice, humans, and other vertebrates and invertebrates. There are a few single-gene mutants known that extend life span in yeast and nematodes; in other experimental systems the character is treated quantitatively, and generally has a low to moderate heritability.
Marc Tatar +6 more
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The American Journal of Medicine, 1963
Abstract The causes of heritable variation in man are mutation and recombination. Further diversity is made possible by the diploid state in which metabolism is influenced by the simultaneous action of homologous genes. Consideration of the events stemming from the action of a single intranuclear gene reveals that the genetic impulse, mediated by a ...
Barton Childs, William J. Young
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Abstract The causes of heritable variation in man are mutation and recombination. Further diversity is made possible by the diploid state in which metabolism is influenced by the simultaneous action of homologous genes. Consideration of the events stemming from the action of a single intranuclear gene reveals that the genetic impulse, mediated by a ...
Barton Childs, William J. Young
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Molecular Genetics and Genetic Variation
2010This chapter contains brief notes on molecular genetics, focusing on those aspects most frequently encountered in genetic epidemiology. The main sections cover the organisation and physical structure of genetic material, the mechanisms involved in transmitting genetic material from one generation to the next, and forms of genetic variation.
M. Dawn Teare, Mohammed-Elfatih Twfieg
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Genetic variation and nutrition
Food Reviews International, 1996Advances in genetics and molecular biology indicate that susceptibility to chronic diseases such as coronary artery disease (CAD), hypertension, diabetes, obesity, osteoporosis, alcoholism, cancer, etc., to a great extent is genetically determined. Studies have shown that 50% of the variance in plasma cholesterol concentration is genetically determined,
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Genetic variation in prehistoric Sardinia
Human Genetics, 2007We sampled teeth from 53 ancient Sardinian (Nuragic) individuals who lived in the Late Bronze Age and Iron Age, between 3,430 and 2,700 years ago. After eliminating the samples that, in preliminary biochemical tests, did not show a high probability to yield reproducible results, we obtained 23 sequences of the mitochondrial DNA control region, which ...
CARAMELLI, DAVID +14 more
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Genetic Variations and Association
2010Publisher Summary This chapter provides information about the human hydroxytryptamine (HT)R6 gene structure, its evolution, and its expression profile in both the brain and in peripheral tissues. The chapter describes the regulatory regions like binding sites for transcription factors (TFs) or for miRNA.
GENNARELLI, Massimo, CATTANEO, Annamaria
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Genetic Variation in Volunteerism
The Sociological Quarterly, 2010Research has shown that prosocial behaviors of various kinds are passed from generation to generation, but the role played by genetics in the transmission of volunteerism has been unexplored. Data from the Midlife in the United States (MIDUS) Twins and Siblings samples are used to estimate genetic heritability of hours volunteered per month.
Son, J., Wilson, J.
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Antimicrobials as promoters of genetic variation
Current Opinion in Microbiology, 2012The main causes of antibiotic resistance are the selection of naturally occurring resistant variants and horizontal gene transfer processes. In recent years, the implications of antibiotic contact or treatment in drug resistance acquisition by bacteria have been gradually more evident.
Jesús Blázquez +3 more
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Genetic variation of regulatory systems
Current Opinion in Genetics & Development, 2009The regulation of gene expression is one of the most important cellular functions that determines developmental and somatic cell fates. Studies that attempt to describe the molecular interactions that govern gene regulation highlight the complexity and multidimensionality of this process.
Dimas, A. S., Dermitzakis, Emmanouil
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Theophylline metabolism: Variation and genetics
Clinical Pharmacology and Therapeutics, 1984Variation of theophylline metabolism in 54 healthy, nonmedicated adults (13 monozygotic [MZ] twin pairs, 11 dizygotic [DZ] twin pairs, and 6 single individuals) was assessed by kinetic study. Elimination rate constant, clearance (Cl), t1/2, and apparent volume of distribution, as well as urine excretion of unchanged theophylline and of the three major ...
Miller, Marvin E. +3 more
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