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Molecular Genetics and Genetic Variation
2010This chapter contains brief notes on molecular genetics, focusing on those aspects most frequently encountered in genetic epidemiology. The main sections cover the organisation and physical structure of genetic material, the mechanisms involved in transmitting genetic material from one generation to the next, and forms of genetic variation.
Mohammed-Elfatih, Twfieg, M Dawn, Teare
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Genetic variation and nutrition
Food Reviews International, 1996Advances in genetics and molecular biology indicate that susceptibility to chronic diseases such as coronary artery disease (CAD), hypertension, diabetes, obesity, osteoporosis, alcoholism, cancer, etc., to a great extent is genetically determined. Studies have shown that 50% of the variance in plasma cholesterol concentration is genetically determined,
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2006
Abstract Genetic variation provides the underpinning of modern biological thought. From evolutionary biologists studying finches in the field, to drug development in the pharmaceutical industry; from the developmental geneticists trying to understand the body plan of a mouse, to the researchers investigating the genetic basis for ...
Marta L Wayne, Michael M Miyamoto
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Abstract Genetic variation provides the underpinning of modern biological thought. From evolutionary biologists studying finches in the field, to drug development in the pharmaceutical industry; from the developmental geneticists trying to understand the body plan of a mouse, to the researchers investigating the genetic basis for ...
Marta L Wayne, Michael M Miyamoto
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American Journal of Primatology, 2004
AbstractThis review summarizes what is currently known concerning genetic variation in gorillas, on both inter‐ and intraspecific levels. Compared to the human species, gorillas, along with the other great apes, possess greater genetic varation as a consequence of a demographic history of rather constant population size. Data and hence conclusions from
Linda, Vigilant, Brenda J, Bradley
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AbstractThis review summarizes what is currently known concerning genetic variation in gorillas, on both inter‐ and intraspecific levels. Compared to the human species, gorillas, along with the other great apes, possess greater genetic varation as a consequence of a demographic history of rather constant population size. Data and hence conclusions from
Linda, Vigilant, Brenda J, Bradley
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Understanding quantitative genetic variation
Nature Reviews Genetics, 2002Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL)--the regions of a chromosome or, ideally, individual sequence variants ...
N H, Barton, P D, Keightley
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Uncovering cryptic genetic variation
Nature Reviews Genetics, 2004Cryptic genetic variation is the dark matter of biology: it is variation that is not normally seen, but that might be an essential source of physiological and evolutionary potential. It is uncovered by environmental or genetic perturbations, and is thought to modify the penetrance of common diseases, the response of livestock and crops to artificial ...
Gibson, Greg, Dworkin, Ian
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Current Opinion in Plant Biology, 2008
Completion of the genomic sequencing of rice has enhanced the discovery of new genes. Wild rice relatives are good sources for extending the genetic variation of cultivated rice. Reproductive barriers are commonly found in distant crosses of rice and are attracting attention.
Kazuyuki, Doi +2 more
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Completion of the genomic sequencing of rice has enhanced the discovery of new genes. Wild rice relatives are good sources for extending the genetic variation of cultivated rice. Reproductive barriers are commonly found in distant crosses of rice and are attracting attention.
Kazuyuki, Doi +2 more
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Annual Review of Genetics, 1995
Life span is subject to genetic modification in yeasts, nematodes, fruit flies, mice, humans, and other vertebrates and invertebrates. There are a few single-gene mutants known that extend life span in yeast and nematodes; in other experimental systems the character is treated quantitatively, and generally has a low to moderate heritability.
J W, Curtsinger +6 more
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Life span is subject to genetic modification in yeasts, nematodes, fruit flies, mice, humans, and other vertebrates and invertebrates. There are a few single-gene mutants known that extend life span in yeast and nematodes; in other experimental systems the character is treated quantitatively, and generally has a low to moderate heritability.
J W, Curtsinger +6 more
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The American Journal of Medicine, 1963
Abstract The causes of heritable variation in man are mutation and recombination. Further diversity is made possible by the diploid state in which metabolism is influenced by the simultaneous action of homologous genes. Consideration of the events stemming from the action of a single intranuclear gene reveals that the genetic impulse, mediated by a ...
B, CHILDS, W J, YOUNG
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Abstract The causes of heritable variation in man are mutation and recombination. Further diversity is made possible by the diploid state in which metabolism is influenced by the simultaneous action of homologous genes. Consideration of the events stemming from the action of a single intranuclear gene reveals that the genetic impulse, mediated by a ...
B, CHILDS, W J, YOUNG
openaire +2 more sources