Results 161 to 170 of about 2,681,594 (304)
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
Gene Therapy for Osteoarthritis: Viral and Non-Viral Delivery Strategies. [PDF]
VirusesZhang M +5 more
europepmc +1 more source
Genetic vectors as a tool in association studies: definitions and application for study of rheumatoid arthritis. [PDF]
Int J Genomics, 2015 Sandalov I, Padyukov L.
europepmc +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source
FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
Unlocking the potential of bacteriophage-based therapeutic gene delivery in hepatocellular carcinoma. [PDF]
J Egypt Natl Canc InstMitra S +7 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Gene therapy as an upcoming technique in the treatment of cancer: A cellular solution to a cellular problem. [PDF]
Mol Ther OncolBedada AT, Genet S.
europepmc +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Mobile genetic elements, cloning vectors and genetic manipulation of bifidobacteria
, 2010 Growth difficulties, because of their fastidious nutritive nature and oxygen sensitivity, and a lack of efficient genetic tools have impeded until recently proper development of molecular studies in Bifidobacterium.
S. Guglielmetti +2 more
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