Results 1 to 10 of about 125,062 (120)

RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging

Journal of Neurodevelopmental Disorders, 2022
Background Regulator of calcineurin 1 (RCAN1) is overexpressed in Down syndrome (DS), but RCAN1 levels are also increased in Alzheimer’s disease (AD) and normal aging.
Helen Wong, Jordan M. Buck, Curtis Borski, Jessica T. Pafford, Bailey N. Keller, Ryan A. Milstead, Jessica L. Hanson, Jerry A. Stitzel, Charles A. Hoeffer   +8 more
doaj   +1 more source

Genome- and transcriptome-wide splicing associations with alcohol use disorder

Scientific Reports, 2023
Genetic mechanisms of alternative mRNA splicing have been shown in the brain for a variety of neuropsychiatric traits, but not substance use disorders.
Spencer B. Huggett, Ami S. Ikeda, Qingyue Yuan, Chelsie E. Benca-Bachman, Rohan H. C. Palmer   +4 more
doaj   +1 more source

Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice

Epigenetics & Chromatin, 2020
Background Maternal smoking of traditional or electronic cigarettes during pregnancy, which constitutes developmental nicotine exposure (DNE), heightens the risk of neurodevelopmental disorders including ADHD, autism, and schizophrenia in children ...
Jordan M. Buck, Heidi C. O’Neill, Jerry A. Stitzel   +2 more
doaj   +1 more source

Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach

Scientific Reports, 2023
Alcohol use (i.e., quantity, frequency) and alcohol use disorder (AUD) are common, associated with adverse outcomes, and genetically-influenced. Genome-wide association studies (GWAS) identified genetic loci associated with both.
Kaitlin E. Bountress, Shannon E. Cusack, Sage E. Hawn, Andrew Grotzinger, Daniel Bustamante, Robert M. Kirkpatrick, Howard J. Edenberg, Ananda B. Amstadter   +7 more
doaj   +1 more source

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Translational Psychiatry, 2022
Multiplex families have higher recurrence risk of schizophrenia compared to the families of sporadic cases, but the source of this increased recurrence risk is unknown.
Mohammad Ahangari, Amanda E. Gentry, Irish Schizophrenia Genomics Consortium, Tan-Hoang Nguyen, Robert Kirkpatrick, Brian C. Verrelli, Silviu-Alin Bacanu, Kenneth S. Kendler, Bradley T. Webb, Brien P. Riley   +9 more
doaj   +1 more source

A statistical genetic investigation of psychiatric resilience

European Journal of Psychotraumatology, 2023
Background: Although trauma exposure (TE) is a transdiagnostic risk factor for many psychiatric disorders, not everyone who experiences TE develops a psychiatric disorder.
Shannon E. Cusack, Fazil Aliev, Daniel Bustamante, Spit for Science Working Group, Danielle M. Dick, Ananda B. Amstadter   +5 more
doaj   +1 more source

Behavioral genetics and taste

BMC Neuroscience, 2007
This review focuses on behavioral genetic studies of sweet, umami, bitter and salt taste responses in mammals. Studies involving mouse inbred strain comparisons and genetic analyses, and their impact on elucidation of taste receptors and transduction ...
Bachmanov Alexander A, Boughter John D
doaj   +1 more source

CyberGenomics: Application of Behavioral Genetics in Cybersecurity

Behavioral Sciences, 2021
Cybersecurity (CS) is a contemporary field for research and applied study of a range of aspects from across multiple disciplines. A cybersecurity expert has an in-depth knowledge of technology but is often also recognized for the ability to view ...
Ingrida Domarkienė, Laima Ambrozaitytė, Linas Bukauskas, Tautvydas Rančelis, Stefan Sütterlin, Benjamin James Knox, Kaie Maennel, Olaf Maennel, Karen Parish, Ricardo Gregorio Lugo, Agnė Brilingaitė   +10 more
doaj   +1 more source

Genetic Control of Collective Behavior in Zebrafish

iScience, 2020
Summary: Many animals, including humans, have evolved to live and move in groups. In humans, disrupted social interactions are a fundamental feature of many psychiatric disorders.
Wenlong Tang, Jacob D. Davidson, Guoqiang Zhang, Katherine E. Conen, Jian Fang, Fabrizio Serluca, Jingyao Li, Xiaorui Xiong, Matthew Coble, Tingwei Tsai, Gregory Molind, Caroline H. Fawcett, Ellen Sanchez, Peixin Zhu, Iain D. Couzin, Mark C. Fishman   +15 more
doaj   +1 more source

Early life adoption shows rearing environment supersedes transgenerational effects of paternal stress on aggressive temperament in the offspring

Translational Psychiatry, 2021
Prenatal experience and transgenerational influences are increasingly recognized as critical for defining the socio-emotional system, through the development of social competences and of their underlying neural circuitries.
Ipshita Zutshi, Sonakshi Gupta, Olivia Zanoletti, Carmen Sandi, Guillaume L. Poirier   +4 more
doaj   +1 more source