Results 281 to 290 of about 5,512,004 (328)

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Isodicentric Y chromosome with SRY duplication in a female with complete gonadal dysgenesis. [PDF]

Mol Cytogenet
Salmaninejad A, Yaghoubi Z, Haghzad T, Latifi M, Bayat R, Esnaashari S, Dalili S.   +6 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

acmgscaler: an R package and Colab for standardized gene-level variant effect score calibration within the ACMG/AMP framework. [PDF]

Bioinformatics
Badonyi M, Marsh JA.
europepmc   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk. [PDF]

PLoS Genet
Carlson JC, Zhang X, Erdogan-Yildirim Z, Beaty TH, Butali A, Buxó CJ, Gowans LJJ, Hecht JT, Long RE, Moreno L, Murray JC, Orioli IM, Padilla C, Wehby GL, Feingold E, Leslie-Clarkson EJ, Weinberg SM, Marazita ML, Shaffer JR.   +18 more
europepmc   +1 more source

Correction: Association between genetically proxied glucosamine and risk of cancer and non-neoplastic disease: a mendelian randomization study. [PDF]

Front Genet
Wu Y, Che Y, Zhang Y, Xiong Y, Shu C, Jiang J, Li G, Guo L, Qiao T, Li S, Li O, Chang N, Zhang X, Zhang M, Qiu D, Xi H, Li J, Chen X, Ye M, Zhang J.   +19 more
europepmc   +1 more source

Editorial: Emerging relevance of molecular profiling in global cancer research and management. [PDF]

Front Genet
Leiphrakpam P, Shukla S, Are C.
europepmc   +1 more source

Response to: Re: 'Development of a risk score based on clinical-pathological features to predict the presence of germline BRCA1/2 pathogenic variants in ovarian cancer patients'. [PDF]

ESMO Open
Innella G, Erini G, De Leo A, Godino L, Caramanna L, Ferrari S, Miccoli S, Perrone AM, Zamagni C, De Iaco P, Turchetti D, Rucci P.   +11 more
europepmc   +1 more source

Lenmeldy (atidarsagene autotemcel) for individuals with early metachromatic leukodystrophy (MLD): A therapeutics bulletin of the American College of Medical Genetics and Genomics (ACMG). [PDF]

Genet Med Open
Gangji RN, Ali QA, Dhamija R, Corado AM, Kharbanda S, ACMG Therapeutics Committee6∗documents@acmg.net.   +5 more
europepmc   +1 more source