Results 111 to 120 of about 1,329,547 (248)

Enrique Cerdá-Olmedo: An Outstanding Scientist and Mentor. [PDF]

Microb Biotechnol
Avalos J, Corrochano LM.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Correction: essential role for endogenous siRNAs during meiosis in mouse oocytes. [PDF]

PLoS Genetics, 2015
PLOS Genetics Staff
doaj   +1 more source

Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms. [PDF]

Genetics
Tautz D, Pallares LF, Andersson L, Barghi N, Barton N, Bay R, Chan YF, Hancock A, Kaiser TS, Koenig D, Kontarakis Z, Liedvogel M, de Meaux J, Nordborg M, Palmer AA, Purugganan M, Schlötterer C, Schmid K, Stainier DYR, Weigel D, Wolf JBW, Ebert D, Gibson G.   +22 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Correction: acal is a long non-coding RNA in JNK signaling in epithelial shape changes during drosophila dorsal closure. [PDF]

PLoS Genetics, 2015
PLOS Genetics Staff
doaj   +1 more source

Correction: Regression approaches for modeling genotype‑environment interaction and making predictions into unseen environments. [PDF]

Theor Appl Genet
Hrachov M, Piepho HP, Rahman NMF, Malik WA.   +3 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Correction: the EJC binding and dissociating activity of PYM is regulated in Drosophila. [PDF]

PLoS Genetics, 2015
PLOS Genetics Staff
doaj   +1 more source

Changes in Italian Nurses' Genetic Knowledge and Perceptions Over a Decade. [PDF]

Nurs Health Sci
Godino L, Magi CE, Ricco M, Turchetti D.
europepmc   +1 more source