Results 181 to 190 of about 2,672,083 (312)

Correction: Altered Ca2+ Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution. [PDF]

PLoS Genetics, 2015
PLOS Genetics Staff
doaj   +1 more source

Employing Common Morality to Address Ethical Issues in Genetics Research With Indigenous People: The Ọmọlúàbí Ideology. [PDF]

Am J Biol Anthropol
Ademola-Popoola IJ, Weyrich LS.
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Author Correction: Viral entry shapes HCMV latency establishment. [PDF]

Nat Commun
Kitsberg Y, Nachshon A, Arazi T, Broennimann K, Fisher T, Wainstein A, Finkel Y, Stern-Ginossar N, Schwartz M.   +8 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Editorial: Exploring the intersection of animal breeding, genetics, and genomics in modern agriculture. [PDF]

Front Genet
Davenport KM, Estrada-Reyes ZM, Wilson CS.   +2 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Correction: Whole-exome sequencing analysis of human semen quality in Russian multiethnic population. [PDF]

Front Genet
Kolmykov S, Vasiliev G, Osadchuk L, Kleschev M, Osadchuk A.   +4 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Author Correction: Allelic variation at a single locus distinguishes spring and winter faba beans. [PDF]

Nat Genet
Zhang H, Windhorst A, Bornhofen E, Tulpova Z, Novak P, Macas J, Simkova H, Nadzieja M, Kim JM, Cram D, Cao Y, Konkin DJF, Sass O, Welna G, Himmelbach A, Mascher M, Link W, Kwon SJ, Yang TJ, Andersen SU, Jayakodi M.   +20 more
europepmc   +1 more source