Results 221 to 230 of about 2,225,252 (353)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Correction to: Pseudomonas aeruginosa adaptation and persistence in the aspergilloma microbiome revealed by integrated multi-omics. [PDF]

G3 (Bethesda)
europepmc   +1 more source

Expanding Clinical and Variant Spectrum of CBX1-Related Syndrome: Report of Three Novel Cases. [PDF]

Clin Genet
Carrillo G, Fujino S, Higgs H, Kabahizi A, Le R, Rabin R, Pappas J, Crunk A, Ranguin K, Mortreux J, AURAGEN Consortium, Lackmy M, Gadia CA, Chau MHK, Rosenfeld JA, Luo X, Izumi K.   +16 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Photograph of the University of Utah Genetics Laboratory

photographPhotograph of one of the earliest locations of the University of Utah Genetics Laboratory. The creation of the Department of Genetics was approved by the Board of Regents in August, 1944.

core  

Correction to: Nematode-resistance loci in upland cotton genomes are associated with structural differences. [PDF]

G3 (Bethesda)
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Correction to: Phenotypic dominance emerges from activity fitness functions and molecular interactions. [PDF]

Genetics
europepmc   +1 more source

Correction to: Comprehensive Genomic Analysis in Hereditary Adrenal and Extra- Adrenal Paragangliomas. [PDF]

Endocr Pathol
Purnaghshband H, Tuzlali E, Deka KB, Bruce JP, Farncombe KM, Gillies B, Prokopec SD, Pugh T, Redmond S, Redondo L, Wang H, Ezzat S, Mete O, Kim RH.   +13 more
europepmc   +1 more source