Results 271 to 280 of about 2,225,252 (353)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Making Genomic Data Actionable in Electronic Health Records: Practical Viewpoint on Standards, Governance, and Implementation. [PDF]

JMIR Med Inform
Menelaou S, Schiza EC, Tomazou M, Neocleous A, Oulas A, Pipis M, Menikou A, Theodosiou A, Papaioannou M, Sismani C, Kyprianou T, Spyrou GM, Schizas CN.   +12 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Retraction: miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2.

PLoS Genetics
PLOS Genetics Editors
doaj   +1 more source

Incorporating genetics and genetic counselling in neurology clinics: a survey of neurologists' perceptions and current practices. [PDF]

BMJ Neurol Open
Gorman M, Maynard L, Horak H, Schaibley V.   +3 more
europepmc   +1 more source

Knowledge, Attitudes, and Perceived Barriers to Genetics and Precision Medicine Among Rural Participants in a Large Academic Biobank: A Mixed-Methods Study. [PDF]

J Pers Med
MacNeal M, Bihlmeyer NA, Haga SB.
europepmc   +1 more source

Correction: Genetic parameters via predictivity in large populations under strong genomic selection. [PDF]

Genet Sel Evol
Gowane G, Hidalgo J, Hollifield MK, Misztal I, Lourenco D.   +4 more
europepmc   +1 more source

Recombination rate and efficiency of linked selection in small and large stickleback populations. [PDF]

PLoS Genet
Wang H, Zhang C, Reid K, Merilä J.
europepmc   +1 more source

Variable Phenotypic Manifestations of Novel Compound Heterozygous CRPPA Variants in Two Iranian Siblings With Limb-Girdle Muscular Dystrophy. [PDF]

Mol Genet Genomic Med
Alagha P, Ahangari F, Kariminejad A, Ghasemi A, Gholami S, Sadatian N, Kariminejad R, Kahrizi K, Okhovat AA, Najmabadi H.   +9 more
europepmc   +1 more source