Results 111 to 120 of about 640,355 (344)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Combined genetic, genomic and physiological approaches to characterize flowering in Fragaria [W324] [PDF]

, 2015
Flowering is a key event for production of seeds or fruits. To date, studies of this process were mainly focused on the molecular mechanisms involved in the control of flowering until now.
Demene, M.N., Denoyes, Béatrice, Gaston, Amèlia, Godin, Christophe, Guédon, Yann, Perrotte, Justine, Petit, Aurélie, Potier, A., Rothan, Christophe, Tenreira, T.   +9 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The role of genetics and genomics in clinical psychiatry

Dialogues in Clinical Neuroscience, 2018
The enormous successes in the genetics and genomics of many diseases have provided the basis for the advancement of precision medicine. Thus, the detection of genetic variants associated with neuropsychiatric disorders, as well as treatment outcome, has ...
M. Hoehe, D. Morris-Rosendahl
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability: an evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG)

Genetics in Medicine, 2021
Kandamurugu Manickam, M. McClain, L. Demmer, Sawona Biswas, H. Kearney, J. Malinowski, L. Massingham, Danny Miller, T. Yu, F. Hisama   +9 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pathways to understanding the genomic aetiology of osteoarthritis [PDF]

, 2017
Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding ...
Acharya, Anderson, Arthritis Research UK, Baker, Baker, Blagojevic, Bonjour, Bos, Buenrostro, Castaño Betancourt, Castaño-Betancourt, Cheng, Chou, Cong, Cooper, Craft, Cross, Daans, Das, Dekker, Delgado-Calle, den Hollander, Dieppe, Dillon, Ding, Egli, Eleftheria Zeggini, Elena Cibrián Uhalte, Encode Project Consortium, Enochson, Ernst, Esbrit, Evangelou, Felson, Felson, Fernández-Tajes, Fleisch, Francis-West, Freilinger, Gaulton, Glyn-Jones, Gobezie, Goldring, Hackinger, Hiligsmann, Hilingsmann, Hindorff, Hopwood, Hunter, Jeffries, Jeremy Mark Wilkinson, Jinek, Karlsson, Kingsbury, Kundaje, Lamas, Lambert, Liao, Lorraine Southam, MacGregor, Mali, Man, Martin, McGovern, McVicker, Meulenbelt, Miyamoto, Moazedi-Fuerst, Mortazavi, Murphy, Murray, Nagalakshmi, Oliveria, Origins of Bone and Cartilage Disease consortium, Phillips, Pickrell, Reynard, Ritter, Robertsson, Rouault, Ruiz-Romero, Rushton, Scanzello, Schaub, Song, Southam, Spector, Spector, Stahl, Steinberg, Steinberg, Stenberg, Stunnenberg, Styrkarsdottir, Styrkarsdottir, Syddall, Tetlow, Tew, Thomas, Tillgren, Uebelhart, Valdes, van Saase, Verma, Vos, Welter, Xu, Zeggini, Zengini, Zhang   +109 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Identification of primary copy number variations reveal enrichment of Calcium, and MAPK pathways sensitizing secondary sites for autism

Egyptian Journal of Medical Human Genetics, 2020
Background Autism is a neurodevelopmental condition with genetic heterogeneity. It is characterized by difficulties in reciprocal social interactions with strong repetitive behaviors and stereotyped interests.
Swati Agarwala, Avinash M. Veerappa, Nallur B. Ramachandra   +2 more
doaj   +1 more source