Results 261 to 270 of about 343,001 (303)
Some of the next articles are maybe not open access.
The genetics and genomics of cancer
Nature Genetics, 2003The past decade has seen great strides in our understanding of the genetic basis of human disease. Arguably, the most profound impact has been in the area of cancer genetics, where the explosion of genomic sequence and molecular profiling data has illustrated the complexity of human malignancies.
Allan, Balmain, Joe, Gray, Bruce, Ponder
openaire +2 more sources
Marsupial genetics and genomics
Trends in Genetics, 2002Marsupials, the 'other' mammals, are found only in Australasia and the Americas. They are quite different from eutherian ('placental') mammals, as well they might be after 130 million years of separate evolution. They display a unique pattern of mammalian organization and development that is reflected by differences in their genomes. Here, we introduce
Marshall Graves, Jennifer A. +1 more
openaire +2 more sources
Genomics and conservation genetics
Trends in Ecology & Evolution, 2006In large part, the relevance of genetics to conservation rests on the premise that neutral marker variation in populations reflects levels of detrimental and adaptive genetic variation. Despite its prominence, this tenet has been difficult to evaluate, until now.
Michael H, Kohn +3 more
openaire +2 more sources
Genetic to genomic vaccination
Vaccine, 1997Our development of genetic immunization (unfortunately named 'DNA'-immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector.
S A, Johnston, M A, Barry
openaire +2 more sources
Genetics and genomics of depression
Metabolism, 2005Depressive disorders are among the most common psychiatric diseases, with prevalence estimates ranging from 5% to a maximum of 20%. Despite their high prevalence and socioeconomic impact, little is known about their etiology. Heritability estimates demonstrate up to a 50% genetic component based on family aggregation and contrasting monozygotic and ...
Pavel, Hamet, Johanne, Tremblay
openaire +2 more sources
Genetics, genomics and metabolomics
2011Metabolomics approaches enable the parallel assessment of the levels of a broad range of metabolites. They have been documented to have great value in phenotyping and diagnostic analyses in plants as well as showing great promise as a tool for bio-prospecting novel pharmaceuticals.
Fernie, A.R., Keurentjes, J.J.B.
openaire +2 more sources
Transplant genetics and genomics
Nature Reviews Genetics, 2017Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide association studies (GWAS) have enabled a deeper understanding of the complex interplay of the donor-recipient ...
Joshua Y C, Yang, Minnie M, Sarwal
openaire +2 more sources
Genomics, genetic epidemiology, and genomic medicine
Clinical Gastroenterology and Hepatology, 2005Medical science is on the threshold of unparalleled progress as a result of the advent of genomics and related disciplines. Human genomics, the study of structure, function, and interactions of all genes in the human genome, promises to improve the diagnosis, treatment, and prevention of disease.
Konstantinos N, Lazaridis +1 more
openaire +2 more sources
2011
Just as the knowledge gleaned from the human genome-sequencing project is beginning to make an enormous contribution to human medicine, genomic tools developed as a result of sequencing the bovine genome and a novel methodology to use this information, called genomic selection, are coming to be used by dairy cattle breeding companies around the world ...
Hayes, B. J., Cocks, B., Goddard, M. E.
openaire +3 more sources
Just as the knowledge gleaned from the human genome-sequencing project is beginning to make an enormous contribution to human medicine, genomic tools developed as a result of sequencing the bovine genome and a novel methodology to use this information, called genomic selection, are coming to be used by dairy cattle breeding companies around the world ...
Hayes, B. J., Cocks, B., Goddard, M. E.
openaire +3 more sources
Genetics and Genomics of Neuroblastoma
2010Neuroblastoma is a pediatric cancer of the developing sympathetic nervous system that most often affects young children. It remains an important pediatric problem because it accounts for approximately 15% of childhood cancer mortality. The disease is clinically heterogeneous, with the likelihood of cure varying greatly according to age at diagnosis ...
CAPASSO, Mario, Sharon J. Diskin
openaire +3 more sources