Results 271 to 280 of about 9,771,651 (424)

Clinical Genetics of Musculoskeletal Disorders

Journal of Orthopaedic Translation, 2016
doaj   +1 more source

Molecular Genetics of Neuroblastoma and the Implications for Clinical Management: A Review of the MSKCC Experience [PDF]

, 2001
Jaume Mora, William L. Gerald, Jing Qin, Nai‐Kong V. Cheung   +3 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Diverse clinical outcomes of eosinophilic patients with T‐cell receptor gene rearrangements: The emerging diagnostic importance of molecular genetics testing [PDF]

, 2001
Joseph H. Butterfield
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Clinical Management and Genetics of Gastrointestinal Polyps in Children

, 2000
Warren Hyer, Iain Beveridge, Paola Domizio, Robin Phillips   +3 more
openalex   +1 more source

Clinical genetics: Compassion, access, science, and advocacy [PDF]

, 2001
Edward R.B. McCabe
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

New Insights Into Genetics and Pathophysiology of Alzheimer's Disease: What Are the Clinical and Therapeutic Implications?

, 2000
Michael Mullan, George T. Grossberg, Ravi Anand, Albert Enz   +3 more
openalex   +2 more sources

Clinical implications of psychiatric genetics in the new millennium – nightmare or nirvana? [PDF]

, 2001
Ian Jones, Lindsey Kent, Moli Paul, Nick Craddock   +3 more
openalex   +1 more source