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Federated generalized linear mixed models for collaborative genome-wide association studies
iScience, 2023 Summary: Federated association testing is a powerful approach to conduct large-scale association studies where sites share intermediate statistics through a central server. There are, however, several standing challenges.
Wentao Li +3 more
doaj +1 more source
Genetics in clinical oncology [PDF]
The Indian Journal of Pediatrics, 1982 This is the first book to provide a thorough grounding in the applications of genetics to cancer medicine, enabling the clinician to convey to patients and their families an understanding of the genetic nature of cancer, and to provide them with accurate advice.
openaire +2 more sources
Genetics in Clinical Trials [PDF]
, 2009 Clinical trials provide the ‘evidence’ in evidence-based medicine. Despite their cost and complexity, clinical trials save society billions of dollars [1]. Recent advances have enabled genome-wide analyses of single nucleotide polymorphisms in complex diseases. Such analyses require large sample sizes and thus depend on collaborative efforts.
James F, Meschia, Katrina, Gwinn
openaire +2 more sources
Genetics, Clinical Features, and Long-Term Outcome of Noncompaction Cardiomyopathy [PDF]
, 2018 BACKGROUND: The clinical outcomes of noncompaction cardiomyopathy (NCCM) range from asymptomatic to heart failure, arrhythmias, and sudden cardiac death. Genetics play an important role in NCCM. OBJECTIVES: This study investigated the correlations
van Spaendonck-Zwarts, KY +36 more
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Genetics in clinical practice: general practitioners' educational priorities in European countries [PDF]
, 2008 PURPOSE: To assess how general practitioners (GPs) from European countries prioritized their genetic educational needs according to their geographic, sociodemographic, and educational characteristics.
Schmidtke, Joerg +41 more
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Clinical genetics in Britain: origins and development [PDF]
, 2010 Clinical genetics has become a major medical specialty in Britain since its beginnings with Lionel Penrose’s work on mental handicap and phenylketonuria (PKU) and John Fraser Robert’s first genetic clinic in 1946.
Harper, PS, Reynolds, LA, Tansey, EM
core +2 more sources
Clinical Genetics In Developing Countries: The Case Of Brazil. [PDF]
, 2015 There are many impediments to the progress of clinical and medical genetics in developing countries. Higher priorities concerning basic health care usually take precedence over genetic diseases and birth defects among medical professionals and public ...
Brunoni, Décio +3 more
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New variants of ABCA12 in harlequin ichthyosis baby
Journal of Pediatric and Neonatal Individualized Medicine, 2018 Harlequin ichthyosis (HI) is an extremely rare genetic skin disorder and the most severe form of a group of disorders, which includes lamellar ichthyosis and congenital ichthyosiform erythroderma.
Sara Peixoto +5 more
doaj +1 more source
Development of clinical genetics in Asia [PDF]
, 2019 This Special Issue on Clinical Genetics in Asia highlights a collection of articles showing the growth, development, and current status of clinical genetics in Asia.
Lai, PS +5 more
core +1 more source
Advances in clinical genetics and genomics
Intelligent Medicine, 2021 Developments in genetics and genomics are progressing at an unprecedented speed. Twenty years ago, the human genome project provided the first glimpses into the human genome sequence and launched a new era of human genetics.
Sen Zhao +6 more
doaj +1 more source