Results 81 to 90 of about 247,762 (263)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The performance of GPT-3.5 and GPT-4 on genetic tests at PhD-level: GPT-4 as a promising tool for genomic medicine and education [PDF]

Journal of Clinical and Basic Research
Background: Natural Language Processing (NLP) has empowered AI models to understand and generate human language, with transformer-based architectures like GPT-3 and GPT-4 marking significant advancements. GPT-4, equipped with a larger parameter count and
Teymoor Khosravi, Arian Rahimzadeh, Farzaneh Motallebi, Fatemeh Vaghefi, Zainab Mohammad Al Sudani, Morteza Oladnabi   +5 more
doaj  

Moving the Fine Print to the Front Page: Transparent Communication of Facial Genetics Research

Advanced Genetics
AI‐enabled facial genetics research has transformative potential for biomedical and forensic applications, but raises serious ethical, legal, and social challenges.
Jennifer K. Wagner, Nina Claessens, Caitlin M. Maloney, Peter Claes   +3 more
doaj   +1 more source

The Joint Contribution of Host Genetics and Probiotics to Pig Growth Performance

Microorganisms
Intestinal probiotics significantly regulate the growth performance of their host, with their composition being influenced by various factors. While many studies have explored how gut microbiota composition affects growth traits such as body weight and ...
Jinyi Han, Mingyu Wang, Shenping Zhou, Zhenyu Wang, Dongdong Duan, Mengyu Li, Xiuling Li, Wenshui Xin, Xinjian Li   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Exploration of biomarkers of Alzheimer’s disease based on orthogonal multi-task canonical correlation analysis

BMC Medical Imaging
As a neurodegenerative disease, Alzheimer’s disease (AD) has many symptoms, such as memory impairment, cognitive decline, and personality change. Image genetics is the correlation analysis between imageology and genetics, and image genetics research can ...
Tao Yang, GuangYu Wan, Xiong Zhou
doaj   +1 more source