Results 71 to 80 of about 17,075 (245)

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Multidisciplinary Treatment for Esophagogastric Junction Cancer From a Dutch Perspective

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Esophagogastric junction (EGJ) cancer is an increasing health burden worldwide. Over the past decade, significant advancements in centralization, multimodal treatment strategies, as well as the widespread adoption of minimally invasive surgical techniques, have led to marked improvements in perioperative outcomes and overall survival of EGJ ...
Hidde C. G. Overtoom, Suzanne S. Gisbertz   +1 more
wiley   +1 more source

Current Status and Future Perspectives of Robotic Surgery for Esophagogastric Cancer in Asia

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Robotic‐assisted surgery (RAS) has moved from an experimental adjunct to an increasingly established component of gastrointestinal (GI) oncological practice in parts of Asia, a region that carries a disproportionately high burden of gastric and esophageal cancer. Asian surgeons have been among the earliest and most prolific contributors to the
Jia Jun Ang, Jimmy Bok Yan So
wiley   +1 more source

The STROGHAT study protocol: An intervention study to evaluate safety, effectiveness and feasibility of treating gambiense HAT seropositive subjects with acoziborole. [version 1; peer review: 2 approved]

Open Research Europe
Background Coordinated efforts in the control of gambiense human African trypanosomiasis (gHAT) have significantly reduced its endemicity. WHO targets interruption of transmission by 2030.
Veerle Lejon, Raquel Inocencio Da Luz, Craig Tipple, Catiane Vander Kelen, Rian Snijders, Nick Van Reet, Stijn Rogé, Paul Verlé, Antoine Tarral, Epco Hasker, Elena Nicco, Dieudonné Mumba, Erick Mwamba Miaka, Charles Kambo, Alain Mpanya, Wilfried Mutombo, Digas Ngolo, Sandra Rembry, Stéphane Hugonnet   +18 more
doaj   +1 more source

Factorization Machine‐Based Active Learning for Functional Materials Design with Optimal Initial Data

Advanced Intelligent Discovery, EarlyView.
This work investigates the optimal initial data size for surrogate‐based active learning in functional material optimization. Using factorization machine (FM)‐based quadratic unconstrained binary optimization (QUBO) surrogates and averaged piecewise linear regression, we show that adequate initial data accelerates convergence, enhances efficiency, and ...
Seongmin Kim, In‐Saeng Suh
wiley   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Characterization and Analysis of PHEX Variants in Patients With Hypophosphatemia in Argentina

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Confirming the underlying molecular etiology of hereditary hypophosphatemia (HH) to provide recurrence risk counseling is highly important. Our aims were to describe the detected variants and their distribution across Argentina and to contrast them with published data.
Silvia Ávila, Sara Fernández, Maximiliano Zeballos, María Georgina Poggio   +3 more
wiley   +1 more source

A scoping literature review of global dengue age-stratified seroprevalence data: estimating dengue force of infection in endemic countriesResearch in context

EBioMedicine
Summary: Background: Dengue poses a significant burden worldwide, and a more comprehensive understanding of the heterogeneity in the intensity of dengue transmission within endemic countries is necessary to evaluate the potential impact of public health
Anna Vicco, Clare McCormack, Belen Pedrique, Isabela Ribeiro, Gathsaurie Neelika Malavige, Ilaria Dorigatti   +5 more
doaj   +1 more source

Memory and Heritage between Jerusalem and Geneva: An Interview with Maryvelma O’Neil on the Virtual Illés Relief Initiative

Review of Middle East Studies
In the late-nineteenth century, a bookbinder from Bratislava named Stefan Illés relocated to the city of Jerusalem in Ottoman Palestine. There he produced what came to be known as the Illés Relief, a miniature three-dimensional model of his adopted city.
openaire   +1 more source