Results 191 to 200 of about 37,169 (239)

Genistein in the Treatment of Hypertension: A Review

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2022
Abstract:Genistein, a natural compound belonging to the group of isoflavones has a confirmed positive effect in such diseases as hormone-dependent cancers, osteoporosis, and cardiovascular diseases, including arterial and pulmonary hypertension. The multiway hypotensive effect is based on vasodilation with simultaneous inhibition of vasoconstriction ...
Paulina Sigowska, Michał Zimoch, Aleksandra Baska, Jakub Kazik, Kamil Leis, Grzegorz Grześk   +5 more
openaire   +2 more sources

Genistein: Dual Role in Women’s Health

Nutrients, 2021
Advanced research in recent years has revealed the important role of nutrients in the protection of women’s health and in the prevention of women’s diseases.
Darlene Dixon, Yitang Yan, Jingli Liu
exaly   +2 more sources

Genistein and hematological malignancies

Cancer Letters, 2010
Genistein is an isoflavanoid from soybeans and promising cancer chemotherapeutic agent. Genistein exposure varies widely because of cultural differences in diet. Hypothetically, this could account for differential cancer risk across ethnic populations.
Wang, Li, Lynn T, Frame, Samantha, Hirsch, Everardo, Cobos   +3 more
openaire   +2 more sources

Cardiovascular Effects of the Phytoestrogen Genistein

Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2004
Phytoestrogenic molecules have received a great deal of attention over the last few years because of their potentially preventive roles against a few of today's most prevalent chronic diseases, namely cardiovascular diseases, osteoporosis and hormone related cancers.
ALTAVILLA, Domenica, CRISAFULLI A, MARINI, Herbert Ryan, ESPOSITO M, D'ANNA, Rosario, CORRADO, Francesco, BITTO, ALESSANDRA, SQUADRITO, Francesco   +7 more
openaire   +3 more sources

Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4′7-O-dioleate in monkeys

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
Soy-derived isoflavone phytoestrogens, such as genistein (4',5,7-trihydroxyisoflavone), have been shown to protect low-density lipoprotein from oxidation. In addition, human plasma was previously shown to be capable of converting genistein into lipophilic fatty acid esters that accumulate in lipoproteins in vitro.
Maija, Badeau, Matti J, Tikkanen, Susan E, Appt, Herman, Adlercreutz, Thomas B, Clarkson, Antti, Hoikkala, Kristiina, Wähälä, Tomi S, Mikkola   +7 more
openaire   +2 more sources

Direct action of genistein on CFTR

Pfl�gers Archiv European Journal of Physiology, 1997
Human cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels were expressed in oocytes from Xenopus laevis after injection of CFTR cRNA and studied with the two-electrode voltage-clamp and the giant patch techniques. The tyrosine kinase inhibitor genistein alone activated a small chloride current in whole oocytes expressing CFTR ...
Weinreich, F., Wood, P., Riordan, J., Nagel, G.   +3 more
openaire   +3 more sources

Pharmacological postconditioning with the phytoestrogen genistein

Journal of Molecular and Cellular Cardiology, 2007
Estrogens are known to activate the phosphatidyl-inosityl 3-kinase (PI3K)/Akt pathway, which is central in the cardioprotection afforded by ischemic postconditioning. Therefore, our goal was to investigate whether a phytoestrogen, genistein, could induce a pharmacological postconditioning and to investigate potential mechanisms.
Tissier, Renaud, Waintraub, X., Couvreur, N., Gervais, M., Bruneval, P., Mandet, C., Zini, R., Enriquez, B., Bruneval, A., Ghaleh, B.   +9 more
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PLASMA PHARMACOKINETICS OF GENISTEIN IN MICE

International Journal of Oncology, 1995
Genistein (GEN) has recently generated considerable interest as a potential agent for the prevention and treatment of cancer. The present investigation was undertaken to determine if the concentrations of drug shown to inhibit the growth of human tumor cell lines by 50% in vitro (IC50=2-27 mu g/ml) can be achieved and sustained systemically in mice. We
J, Supko, L, Malspeis
openaire   +2 more sources

Genistein attenuates choroidal neovascularization

The Journal of Nutritional Biochemistry, 2014
Genistein is a dietary-derived flavonoid abundantly present in soybeans and known to possess various biological effects including anti-inflammation and anti-angiogenic activity. To investigate the effects of genistein on intraocular neovascularization, we used an animal model of laser-induced choroidal neovascularization (CNV).
Satoshi, Kinoshita, Kousuke, Noda, Yoshiaki, Tagawa, Saori, Inafuku, Yoko, Dong, Junichi, Fukuhara, Zhenyu, Dong, Ryo, Ando, Atsuhiro, Kanda, Susumu, Ishida   +9 more
openaire   +2 more sources

Reactions of Genistein with Alkylperoxyl Radicals

Chemical Research in Toxicology, 2000
Antioxidant actions of the soy isoflavone genistein are believed to contribute to its overall chemopreventive activity. However, the mechanisms of its antioxidant reactions remain unknown. The objective of this study was to characterize the reaction products of genistein (5,7,4'-trihydroxyisoflavone) with peroxyl radicals generated by thermolysis of 2 ...
A, Arora, S, Valcic, S, Cornejo, M G, Nair, B N, Timmermann, D C, Liebler   +5 more
openaire   +2 more sources