Results 211 to 220 of about 29,159 (222)

Genistein: A Boon for Mitigating Ischemic Stroke

Current Topics in Medicinal Chemistry, 2015
In last decades, diet and dietary components have been regarded as important strategies to prevent the development or mitigate numerous chronic diseases, including inflammation, cardiovascular pathologies, cancer, etc. One of the most common dietary components of Asian population is soy.
Nabavi S. F., Daglia M., Tundis R., Loizzo M. R., Sobarzo-Sanchez E., Orhan I. E., Nabavi S. M.   +6 more
openaire   +7 more sources

Lactational transfer of the soy isoflavone, genistein, in Sprague–Dawley rats consuming dietary genistein

Reproductive Toxicology, 2006
Exposures of Sprague-Dawley rats to the soy isoflavone, genistein, throughout the entire lifespan have produced a number of effects on reproductive tissues, immune function, neuroendocrine function and behavior. Our previous studies investigated pharmacokinetics and disposition of genistein during adult and fetal periods and this study describes the ...
Retha R. Newbold, Nathan C. Twaddle, Mona I. Churchwell, Daniel R. Doerge, K. Barry Delclos   +4 more
openaire   +3 more sources

ChemInform Abstract: Novel Synthesis of the Isoflavone Genistein.

ChemInform, 2010
AbstractA novel five‐step sequence for the synthesis of genistein (VIb) from ketone (Ia) involves formation of the enamino ketone (III) followed by ring closure and Suzuki coupling.
Ronny Priefer, Vincent M. Carroll, Jeffrey D. St. Denis, James S. Gordon   +3 more
openaire   +3 more sources

A Bivalent Role of Genistein in Sprouting Angiogenesis

Planta Medica, 2018
AbstractThe effects of genistein on angiogenesis remain poorly understood. Some studies claim an antiangiogenic effect and others claim a pro-angiogenic one. Thus, the aim of this study was to determine if genistein may exhibit bivalent angiogenic effects. To address this question, genistein angiogenic modulatory effects were examined using an in vitro
Berndt, Sarah, Issa, Mark Elia, Carpentier, Gilles, Cuendet Licea, Muriel   +3 more
openaire   +4 more sources

Extraction and Quantification of Daidzein and Genistein in Food

Analytical Biochemistry, 1998
A simple analytical method has been developed for routine quantification of a broad range of concentrations of the isoflavones daidzein and genistein in food. The synthetic glucosides daidzin and genistin were used as internal standards, combined with each food prior to extraction.
Sheila Bingham, Les Bluck, J. Liggins, W. A. Coward   +3 more
openaire   +3 more sources

The impact of genistein on osteoporosis.

CABI Reviews, 2009
Abstract Genistein, one of the isoflavones, has an activity in terms of affinity to oestrogen receptor α (ERα) and oestrogen receptor β (ERβ) and a biological activity similar to oestrogen. The serum concentrations of genistein in Japanese people range from nanomolar to millimolar levels, since soya proteins are absorbed in the ...
openaire   +2 more sources

Topoisomerase poisoning by genistein in the intestine of rats

Toxicology Letters, 2016
The isoflavone genistein has been shown to act as topoisomerase II poison in various cell lines. Here, we address the question whether genistein is able to affect topoisomerase II in vivo. Juvenile male Wistar rats received either a single dose of genistein subcutaneously (s.c.; 10 mg/kg BW) or a lifelong isoflavone-rich diet encompassing in utero ...
Simone A. Baechler, Sebastian T. Soukup, Almut F. Molzberger, Sabine E. Kulling, Patrick Diel, Doris Marko   +5 more
openaire   +2 more sources

Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitro

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2003
Atherosclerosis is initiated by the uptake and retention of oxidized low-density lipoprotein (LDL) into the arterial intima. We have previously shown that dietary isoflavone phytoestrogens inhibit LDL oxidation in vitro. The inhibition could have been caused by undetected isoflavone metabolites associated with lipoproteins.
Matti Jauhiainen, Maija Kaamanen, Matti J. Tikkanen, Herman Adlercreutz   +3 more
openaire   +3 more sources

Genistein-Induced Changes in Gene Expression in Panc 1 Cells at Physiological Concentrations of Genistein

Pancreas, 2004
To investigate the effect of genistein on gene expression in Panc 1 cells using microarray technology.Panc 1 cells were treated with 10 micromol/L genistein or DMSO (vehicle control) for 0, 1, 3, 6, or 12 hours. Total RNA from each sample was isolated, and biotin-labeled probes were hybridized to the human genome U133A chip, after which the chip was ...
Koji Yoshida, Tomoaki Wada, Hideo Nagai, Fumihiro Sata, Naohiro Sata, Jianfeng Bai, Reiko Kishi, Hiroyuki Mano   +7 more
openaire   +3 more sources

Effect of Genistein and Genistein Analogs on Growth of Human Prostate Tissue In Vitro

Journal of Medicinal Food, 1999
Gordana Olbina, Jack Geller, Dusan Miljkovic, Robert M. Hoffman   +3 more
openaire   +3 more sources