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BioDrugs, 2002
The sequencing of entire bacterial genomes is becoming increasingly routine, promising to revolutionise approaches to identifying putative antimicrobial drug targets. In silico methods can be used to identify putative gene products by comparing sequences of biochemically characterised enzymes and proteins with data produced by sequencing projects ...
Brian, Fritz, Gregory A, Raczniak
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The sequencing of entire bacterial genomes is becoming increasingly routine, promising to revolutionise approaches to identifying putative antimicrobial drug targets. In silico methods can be used to identify putative gene products by comparing sequences of biochemically characterised enzymes and proteins with data produced by sequencing projects ...
Brian, Fritz, Gregory A, Raczniak
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The Pyrosequencing Protocol for Bacterial Genomes
2015The pyrosequencing methodology was applied in 2005 by 454 Lifesciences to the emerging field of next generation sequencing (NGS), revolutionizing the way of DNA sequencing. In the last years the same strategy grew up and was technologically updated, reaching a high throughput in terms of amount of generated sequences (reads) per run and in terms of ...
Rizzi, Ermanno
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Order and disorder in bacterial genomes
Current Opinion in Microbiology, 2004The availability of sequenced bacterial genomes allows a deeper understanding of their organizational features that are related with fundamental cellular processes such as coordinated gene expression, chromosome replication and cell division. Nevertheless, recent genome comparisons and experimental work highlighted the fluidity of bacterial chromosomes,
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Bacterial genomes: evolution of pathogenicity
Current Opinion in Plant Biology, 2011Bacterial pathogens continue to pose a major threat to economically important plant resources. Disease outbreaks can occur through rapid evolution of a pathogen to overcome host defences. The advent of genome sequencing, especially next-generation technologies, has seen a revolution in the study of plant pathogen evolution over the past five years ...
Dawn L, Arnold, Robert W, Jackson
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Bacterial pathogen genomics and vaccines
British Medical Bulletin, 2002Infectious diseases remain a major cause of deaths and disabilities in the world, the majority of which are caused by bacteria. Although immunisation is the most cost effective and efficient means to control microbial diseases, vaccines are not yet available to prevent many major bacterial infections.
Richard, Moxon, Rino, Rappuoli
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2015
The study of bacterial genetics has revolutionised with the development of genome sequencing, which let us catalogue the gene content of various clinically and industrially important bacteria and opened up the field of comparative genomics. The research findings on bacterial genetics were further enhanced by the development of allied techniques that ...
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The study of bacterial genetics has revolutionised with the development of genome sequencing, which let us catalogue the gene content of various clinically and industrially important bacteria and opened up the field of comparative genomics. The research findings on bacterial genetics were further enhanced by the development of allied techniques that ...
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Operon Prediction in Bacterial Genomes
2008Operons are sets of adjacent genes that encode proteins with related metabolic functions. Operon prediction may be useful for understanding the systems of regulation and for genome annotation. In this work, we present an extension of the PROCSIMO tool to allow the operon prediction in bacterial genomes based on the similarity evaluation between pairs ...
Matheus B. S. Barros +2 more
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Beyond horizontal gene transfer: the role of plasmids in bacterial evolution
Nature Reviews Microbiology, 2021Jeronimo Rodríguez-Beltrán +2 more
exaly