Results 1 to 10 of about 6,892 (155)

Helminth Genomics: The Implications for Human Health [PDF]

PLoS Neglected Tropical Diseases, 2009
More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, loss of productivity among the workforce, and maintenance
Brindley, Paul J, Mitreva, Makedonka, Ghedin, Elodie, Lustigman, Sara   +3 more
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Revisiting the Phylogenetic History of Helminths Through Genomics, the Case of the New Echinococcus oligarthrus Genome [PDF]

Frontiers in Genetics, 2019
The first parasitic helminth genome sequence was published in 2007; since then, only ∼200 genomes have become available, most of them being draft assemblies. Nevertheless, despite the medical and economical global impact of helminthic infections, parasite genomes in public databases are underrepresented.
Maldonado, Lucas Luciano, Arrabal, Juan Pablo, Rosenzvit, Mara Cecilia, De Oliveira, Guilherme Corrêa, Kamenetzky, Laura   +4 more
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MHC Diversity Across Time and Space. [PDF]

Ecol Evol
The article discusses the importance of genetic diversity, particularly in the Major Histocompatibility Complex (MHC) loci, in maintaining evolution and protecting against infectious disease. We review the emerging research on geographic and temporal patterns of MHC diversity in natural populations and highlight the consequences of lower MHC diversity ...
Cortazar-Chinarro M, King KC, Lillie M.
europepmc   +2 more sources

Tackling Hypotheticals in Helminth Genomes [PDF]

Trends in Parasitology, 2018
Advancements in genome sequencing have led to the rapid accumulation of uncharacterized 'hypothetical proteins' in the public databases. Here we provide a community perspective and some best-practice approaches for the accurate functional annotation of uncharacterized genomic sequences.
Palevich, Nikola, Britton, Collette, Kamenetzky, Laura, Mitreva, Makedonka, de Moraes Mourão, Marina, Bennuru, Sasisekhar, Quack, Thomas, Scholte, Larissa Lopes Silva, Tyagi, Rahul, Slatko, Barton E.   +9 more
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Population genomics of helminth parasites

Journal of Helminthology, 2023
Abstract Next generation sequencing technologies have facilitated a shift from a few targeted loci in population genetic studies to whole genome approaches. Here, we review the types of questions and inferences regarding the population biology and evolution of parasitic helminths being addressed within the field of population genomics.
C.S. Thorn, R.W. Maness, J.M. Hulke, K.E. Delmore, C.D. Criscione   +4 more
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Parasitic helminth genomics

Parasitology, 1999
The initiation of genome projects on helminths of medical importance promises to yield new drug targets and vaccine candidates in unprecedented numbers. In order to exploit this emerging data it is essential that the user community is aware of the scope and quality of data available, and that the genome projects provide analyses of the raw data to ...
Jennifer Daub, Jennifer Daub, David B. Guiliano, Mark Blaxter, Martin Aslett   +4 more
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Post-genomic progress in helminth parasitology [PDF]

Parasitology, 2020
AbstractHelminth parasitology is an important discipline, which poses often unique technical challenges. One challenge is that helminth parasites, particularly those in humans, are often difficult to obtain alive and in sufficient quantities for study; another is the challenge of studying these organisms in vitro – no helminth parasite life cycle has ...
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Evaluation of genome skimming to detect and characterise human and livestock helminths

International Journal for Parasitology, 2023
The identification of gastrointestinal helminth infections of humans and livestock almost exclusively relies on the detection of eggs or larvae in faeces, followed by manual counting and morphological characterisation to differentiate species using microscopy-based techniques.
Marina Papaiakovou, Natalia Fraija-Fernández, Katherine James, Andrew G. Briscoe, Andie Hall, Timothy P. Jenkins, Julia Dunn, Bruno Levecke, Zeleke Mekonnen, Piet Cools, Stephen R. Doyle, Cinzia Cantacessi, D.T.J. Littlewood   +12 more
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WormBase 2016: expanding to enable helminth genomic research [PDF]

Nucleic Acids Research, 2015
WormBase (www.wormbase.org) is a central repository for research data on the biology, genetics and genomics of Caenorhabditis elegans and other nematodes. The project has evolved from its original remit to collect and integrate all data for a single species, and now extends to numerous nematodes, ranging from evolutionary comparators of C.
Kevin L. Howe, Bruce J. Bolt, Scott Cain, Juancarlos Chan, Wen J. Chen, Paul Davis, James Done, Thomas Down, Sibyl Gao, Christian Grove, Todd W. Harris, Ranjana Kishore, Raymond Lee, Jane Lomax, Yuling Li, Hans-Michael Muller, Cecilia Nakamura, Paulo Nuin, Michael Paulini, Daniela Raciti, Gary Schindelman, Eleanor Stanley, Mary Ann Tuli, Kimberly Van Auken, Daniel Wang, Xiaodong Wang, Gary Williams, Adam Wright, Karen Yook, Matthew Berriman, Paul Kersey, Tim Schedl, Lincoln Stein, Paul W. Sternberg   +33 more
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Advances in the study of helminth mitochondrial genomes and their associated applications [PDF]

Chinese Science Bulletin, 2012
Helminths, including flatworms and roundworms, are abundant organisms that have a variety of life histories. Of these, the genera Schistosoma, Echinococcus, Trichinella are notable parasites of veterinary and medical importance, and cause substantial socioeconomic losses throughout China and the rest of the world.
Wan-Zhong Jia, Xing-Wei Ni, Lou Zhongzi, Xuepeng Cai, Hongbin Yan, Ping Cao, Hongmin Li   +6 more
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