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Mitochondrial genomes of human helminths and their use as markers in population genetics and phylogeny

Acta Tropica, 2000
To date, over 100 complete metazoan mitochondrial (mt) genomes of different phyla have been reported. Here, we briefly summarise mt gene organisation in the Metazoa and review what is known of the mt genomes of nematodes and flatworms parasitic in humans.
Le, Thanh H.   +2 more
openaire   +4 more sources

Sequencing and Annotation of Mitochondrial Genomes from Individual Parasitic Helminths

2014
Mitochondrial (mt) genomics has significant implications in a range of fundamental areas of parasitology, including evolution, systematics, and population genetics as well as explorations of mt biochemistry, physiology, and function. Mt genomes also provide a rich source of markers to aid molecular epidemiological and ecological studies of key ...
Aaron R. Jex   +2 more
openaire   +3 more sources

The complete mitochondrial genome of the dwarf tapeworm Hymenolepis nana—a neglected zoonotic helminth

Parasitology Research, 2015
Hymenolepis nana, commonly known as the dwarf tapeworm, is one of the most common tapeworms of humans and rodents and can cause hymenolepiasis. Although this zoonotic tapeworm is of socio-economic significance in many countries of the world, its genetics, systematics, epidemiology, and biology are poorly understood.
Xing-Quan Zhu   +4 more
openaire   +2 more sources

Functional Genomics Tools for Haemonchus contortus and Lessons From Other Helminths

2016
The availability of genome and transcriptome data for parasitic nematodes, including Haemonchus contortus, has highlighted the need to develop functional genomics tools. Comparative genomic analysis, particularly using data from the free-living nematode Caenorhabditis elegans, can help predict gene function.
Brett Roberts   +2 more
openaire   +3 more sources

Producing parasitic helminth reference and draft genomes at the Wellcome Trust Sanger Institute

Parasite Immunology, 2012
SummaryThe Wellcome Trust Sanger Institute (WTSI) is producing de novo reference quality genomes for parasitic helminth species from platyhelminth tapeworms (cestodes), flukes (trematodes) and roundworms (nematodes) primarily using second‐generation (Illumina and 454) sequencing technologies.
Nancy Holroyd, Alejandro Sanchez-Flores
openaire   +3 more sources

Using WormBase ParaSite: An Integrated Platform for Exploring Helminth Genomic Data

2018
WormBase ParaSite ( parasite.wormbase.org ) is a comprehensive resource for the genomes of parasitic nematodes and flatworms (helminths). It currently includes genomic data for over 100 helminth species, adding value by way of consistent functional annotation, gene comparative analysis and gene expression analysis.
Myriam Shafie   +5 more
openaire   +3 more sources

Long PCR amplification of the entire mitochondrial genome from individual helminths for direct sequencing

Nature Protocols, 2007
Exploring mitochondrial (mt) genomes has significant implications for various fundamental research areas, including mt biochemistry and physiology, and, importantly, such genomes provide a rich source of markers for population genetics and systematic studies. Although some progress has been made, there is a paucity of information on mt genomes for many
Min Hu   +3 more
openaire   +3 more sources

Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression

International Journal for Parasitology, 2003
The control of helminth diseases of people and livestock continues to rely on the widespread use of anti-helminthic drugs. However, concerns with the appearance of drug resistant parasites and the presence of pesticide residues in food and the environment, has given further incentive to the goal of discovering molecular vaccines against these pathogens.
Grace Mulcahy   +9 more
openaire   +2 more sources

Estimating the number of breeders from helminth larvae with genomic data

2023
AbstractEffective control of helminth infections requires the application of mathematical models to inform control efforts and policy, the development of product profiles for new drugs, and the monitoring of existing drugs for resistance. Key to the success of these approaches is accurately estimating the number of worms within a host, as well as ...
Tristan. P. W. Dennis   +11 more
openaire   +1 more source

Parasitic Helminths: From Genomes to Vaccines

Parasitology Today, 1998
Malcolm W. Kennedy   +2 more
openaire   +3 more sources

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