Results 11 to 20 of about 16,403 (216)

Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths [PDF]

BMC Genomics, 2019
Background Helminth infections affect ~ 60% of the human population that lives in tropical and subtropical regions worldwide. These infections result in diseases like schistosomiasis, lymphatic filariasis, river blindness and echinococcosis.
Preeti Goel, Suhel Parvez, Amit Sharma
doaj   +3 more sources

Chromosome-length genome assembly of Teladorsagia circumcincta – a globally important helminth parasite in livestock

BMC Genomics, 2023
Background Gastrointestinal (GIT) helminthiasis is a global problem that affects livestock health, especially in small ruminants. One of the major helminth parasites of sheep and goats, Teladorsagia circumcincta, infects the abomasum and causes ...
Shamshad Ul Hassan, Eng Guan Chua, Erwin A. Paz, Chin Yen Tay, Johan C. Greeff, Dieter G. Palmer, Olga Dudchenko, Erez Lieberman Aiden, Graeme B. Martin, Parwinder Kaur   +9 more
doaj   +4 more sources

Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing [PDF]

Frontiers in Genetics, 2019
Whole-genome sequencing is being rapidly applied to the study of helminth genomes, including de novo genome assembly, population genetics, and diagnostic applications.
Stephen R. Doyle, Geetha Sankaranarayanan, Fiona Allan, Duncan Berger, Pablo D. Jimenez Castro, Pablo D. Jimenez Castro, James Bryant Collins, Thomas Crellen, Thomas Crellen, María A. Duque-Correa, Peter Ellis, Tegegn G. Jaleta, Roz Laing, Kirsty Maitland, Catherine McCarthy, Tchonfienet Moundai, Ben Softley, Elizabeth Thiele, Philippe Tchindebet Ouakou, John Vianney Tushabe, John Vianney Tushabe, Joanne P. Webster, Adam J. Weiss, James Lok, Eileen Devaney, Ray M. Kaplan, James A. Cotton, Matthew Berriman, Nancy Holroyd   +28 more
doaj   +5 more sources

Revisiting the Phylogenetic History of Helminths Through Genomics, the Case of the New Echinococcus oligarthrus Genome [PDF]

Frontiers in Genetics, 2019
The first parasitic helminth genome sequence was published in 2007; since then, only ∼200 genomes have become available, most of them being draft assemblies.
Lucas L. Maldonado, Juan Pablo Arrabal, Mara Cecilia Rosenzvit, Guilherme Corrêa De Oliveira, Laura Kamenetzky   +4 more
doaj   +4 more sources

Tackling Hypotheticals in Helminth Genomes [PDF]

Trends in Parasitology, 2018
Advancements in genome sequencing have led to the rapid accumulation of uncharacterized 'hypothetical proteins' in the public databases. Here we provide a community perspective and some best-practice approaches for the accurate functional annotation of uncharacterized genomic sequences.
Palevich, Nikola, Britton, Collette, Kamenetzky, Laura, Mitreva, Makedonka, de Moraes Mourão, Marina, Bennuru, Sasisekhar, Quack, Thomas, Scholte, Larissa Lopes Silva, Tyagi, Rahul, Slatko, Barton E.   +9 more
openaire   +4 more sources

Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture. [PDF]

Mol Ecol Resour
AbstractNew approaches are urgently needed to enrich rare or low-abundant DNA in complex samples. Soil-transmitted helminths (STHs) inhabit heterogeneous environments, including the gastrointestinal tract of their host as adults and are excreted as eggs and larvae in faeces, complicating our understanding of their biology and the use of genetic tools ...
Papaiakovou M, Waeschenbach A, Anderson RM, Cools P, Mekonnen Z, Littlewood DTJ, Cantacessi C, Doyle SR.   +7 more
europepmc   +2 more sources

Population genomics of helminth parasites

Journal of Helminthology, 2023
Abstract Next generation sequencing technologies have facilitated a shift from a few targeted loci in population genetic studies to whole genome approaches. Here, we review the types of questions and inferences regarding the population biology and evolution of parasitic helminths being addressed within the field of population genomics.
C.S. Thorn, R.W. Maness, J.M. Hulke, K.E. Delmore, C.D. Criscione   +4 more
openaire   +2 more sources

Genome-Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms-Fish Hosts System and Drug Target Identification. [PDF]

Adv Sci (Weinh)
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Zhang D, Zhao JM, Xiang CY, Ma YW, Lei HP, Shi YY, Zhou S, Zeng X, Chen J, Liu F, Zeng B, Song R, Hu Y, Zhang F, Liu X, Li WX, Wang GT, Jakovlić I.   +17 more
europepmc   +2 more sources

Parasitic helminth genomics

Parasitology, 1999
The initiation of genome projects on helminths of medical importance promises to yield new drug targets and vaccine candidates in unprecedented numbers. In order to exploit this emerging data it is essential that the user community is aware of the scope and quality of data available, and that the genome projects provide analyses of the raw data to ...
Blaxter, M., Aslett, M., Guiliano, D., Daub, J.   +3 more
openaire   +4 more sources

Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of Gambian infants [PDF]

, 2008
Background There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective.
A Lalvani, A Marchant, AM Cooper, AP Soares, Arnaud Marchant, AS Pym, AV Hill, B Wu, Ben Marais, Chris Finan, D Elias, D O'Donovan, E Jouanguy, G Dai, G Sirugo, GA Colditz, GA Poland, GF Black, GF Black, H Fletcher, H Mahomed, I Malhotra, J Vekemans, JJ Ellner, LB Reichman, LC Rodrigues, M Bonecini-Almeida, M Ota, MA Behr, MA Horwitz, Martin O. C. Ota, Melanie J. Newport, MJ Newport, MJ Newport, MOC Ota, NE Beveridge, PC Hill, PEM Fine, RE Weir, RE Weir, RH Brookes, S Dupuis, S Mallal, SE Dorman, ST Bennett, TB Stop, V Davids   +46 more
core   +10 more sources