Results 41 to 50 of about 6,892 (155)

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms.

PLoS Neglected Tropical Diseases, 2020
The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N.
Jayden Logan, Mark S Pearson, Srikanth S Manda, Young-Jun Choi, Matthew Field, Ramon M Eichenberger, Jason Mulvenna, Shivashankar H Nagaraj, Ricardo T Fujiwara, Pedro Gazzinelli-Guimaraes, Lilian Bueno, Vitor Mati, Jeffrey M Bethony, Makedonka Mitreva, Javier Sotillo, Alex Loukas   +15 more
doaj   +1 more source

How do parasites and predators choose their victim? A trade‐off between quality and vulnerability across antagonistic interactions

Biological Reviews, EarlyView.
ABSTRACT From blood‐sucking lice and food‐stealing gulls to pandemic‐inducing viruses and egg‐eating snakes: parasites and predators are ubiquitous in shaping ecology and evolution. Fundamental to these interactions is the way in which parasites and predators choose their victim. Here, I argue that a trade‐off between host quality and vulnerability can
Mairenn C. Attwood
wiley   +1 more source

Dad's legacy: Epigenetic reprogramming and paternal inflammatory memory in offspring health

Journal of Internal Medicine, EarlyView.
Abstract Over the past decade, numerous reports have highlighted intergenerational and even transgenerational epigenetic effects resulting from parental exposure to diets, toxins, and stress. In many cases, these parentally induced phenotypes do not seem to confer an obvious benefit, making it challenging to understand the evolutionary drivers behind ...
Shamila D. Alipoor, Parisa Norouzitallab, Anita Öst, Maria Lerm   +3 more
wiley   +1 more source

Resources Modulate Developmental Shifts but Not Infection Tolerance Upon Co‐Infection in an Insect System

Molecular Ecology, EarlyView.
ABSTRACT Energetic resources within organisms fuel both parasite growth and immune responses against them, but it is unclear whether energy allocation is sufficient to explain changes in infection outcomes under the threat of multiple parasites. We manipulated diet in flour beetles (Tribolium confusum) infected with two natural parasites and used a ...
Nora K. E. Schulz, Danial Asgari, Siqin Liu, Stephanie S. L. Birnbaum, Alissa M. Williams, Arun Prakash, Ann T. Tate   +6 more
wiley   +1 more source

Helminth genome analysis: the current status of the filarial and schistosome genome projects

Parasitology, 1999
Genome projects for the parasitic helminths Brugia malayi (a representative filarial nematode) and Schistosoma were initiated in 1995 by the World Health Organization with the ultimate objectives of identifying new vaccine candidates and drug targets and of developing low resolution genome maps.
S. A. WILLIAMS, null THE FILARIAL GENOME PROJECT, D. A. JOHNSTON, null THE SCHISTOSOME GENOME PROJECT   +3 more
openaire   +2 more sources

Helminth genome analysis reveals conservation of extracellular vesicle biogenesis pathways but divergence of RNA loading machinery between phyla [PDF]

International Journal for Parasitology, 2020
A comparative genomics approach was used to determine whether established extracellular vesicle biogenesis pathways are conserved in helminths. This revealed conservation of membrane and cytoskeletal organising proteins as well as the endosomal sorting complex required for transport previously described in mammalian cells. Domain level analysis of this
Bennett, Adam, de la Torre Escudero, Eduardo, Robinson, Mark   +2 more
openaire   +5 more sources

Homology-based annotation of non-coding RNAs in the genomes of Schistosoma mansoni and Schistosoma japonicum

BMC Genomics, 2009
Background Schistosomes are trematode parasites of the phylum Platyhelminthes. They are considered the most important of the human helminth parasites in terms of morbidity and mortality.
Santana Clara, Brindley Paul J, Hertel Jana, Rose Dominic, Marz Manja, Copeland Claudia C, Kehr Stephanie, Attolini Camille, Stadler Peter F   +8 more
doaj   +1 more source

In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection.

PLoS Pathogens, 2020
Trichuris trichiura is a parasite that infects 500 million people worldwide, leading to colitis, growth retardation and Trichuris dysentery syndrome. There are no licensed vaccines available to prevent Trichuris infection and current treatments are of ...
Ayat Zawawi, Ruth Forman, Hannah Smith, Iris Mair, Murtala Jibril, Munirah H Albaqshi, Andrew Brass, Jeremy P Derrick, Kathryn J Else   +8 more
doaj   +1 more source

Genomic Analysis of Hair Sheep From West/Central Africa Reveals Unique Genetic Diversity and Ancestral Links to Breed Formation in the Caribbean

Molecular Ecology, EarlyView.
ABSTRACT Cameroon Blackbelly sheep are a domestic breed of hair sheep from West/Central Africa. They are popular with small‐holder farmers in Cameroon as they are highly resilient to local environmental challenges and are prolific a‐seasonal breeders.
Pamela Wiener, Juliane Friedrich, Melissa M. Marr, Gustave Simo, Vincent N. Tanya, Keith T. Ballingall, Pavel Flegontov, Benjamin D. Rosen, Guillaume Sallé, Gordon Spangler, Curtis P. Van Tassell, Mazdak Salavati, Félix Meutchieye, Emily L. Clark   +13 more
wiley   +1 more source

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, EarlyView.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source