Results 71 to 80 of about 16,403 (216)

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, Volume 24, Issue 1, Page 224-238, January 2026.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

Highly efficient transgene‐free ErCas12a RNP‐protoplast genome editing and single‐cell regeneration in Nicotiana benthamiana for glyco‐engineering

Plant Biotechnology Journal, Volume 24, Issue 1, Page 239-255, January 2026.
Summary Nicotiana benthamiana serves as a unique platform for biopharmaceutical production, offering advantages such as efficient and scalable protein synthesis. In addition, custom N‐glycans can be engineered on biopharmaceutical glycoproteins. Yet, plant‐native glycosyltransferases and glycoside hydrolases need to be removed to prevent undesired ...
Lukas C. Blumberg, Geartsje M. Bakker, Alex van der Kaaij, Élyse Gariépy, Henri van de Geest, Erik J. Slootweg, Ferdinand C. O. Los, Lotte B. Westerhof, Ruud H. P. Wilbers   +8 more
wiley   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Genome-wide insights into adaptive hybridisation across the Schistosoma haematobium group in West and Central Africa.

PLoS Neglected Tropical Diseases, 2022
Schistosomiasis remains a public health concern across sub-Saharan Africa; current control programmes rely on accurate mapping and high mass drug administration (MDA) coverage to attempt disease elimination.
Toby Landeryou, Muriel Rabone, Fiona Allan, Rosie Maddren, David Rollinson, Bonnie L Webster, Louis-Albert Tchuem-Tchuenté, Roy M Anderson, Aidan M Emery   +8 more
doaj   +1 more source

Global Warming Affects the Pathogenesis of Important Fish Diseases in European Aquaculture

Reviews in Aquaculture, Volume 18, Issue 1, January 2026.
The effect of global warming on pathogens and their fish hosts that could exacerbate the negative outcomes for aquaculture. Changes in farming practices and the development of innovative mitigation tools may prove essential to cope with the effects and impacts of rising water temperatures on fish diseases in Europe.
George Rigos, Francesc Padrós, Maria Constenla, Ana Jerončić, Dimitra Kogiannou, Sofia Consuegra, Mikolaj Adamek, Ivona Mladineo   +7 more
wiley   +1 more source

Helminth genome analysis: the current status of the filarial and schistosome genome projects

Parasitology, 1999
Genome projects for the parasitic helminths Brugia malayi (a representative filarial nematode) and Schistosoma were initiated in 1995 by the World Health Organization with the ultimate objectives of identifying new vaccine candidates and drug targets and of developing low resolution genome maps.
S. A. WILLIAMS, null THE FILARIAL GENOME PROJECT, D. A. JOHNSTON, null THE SCHISTOSOME GENOME PROJECT   +3 more
openaire   +1 more source

Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons.

PLoS Neglected Tropical Diseases, 2020
Filarial parasitic nematodes (Filarioidea) cause substantial disease burden to humans and animals around the world. Recently there has been a coordinated global effort to generate, annotate, and curate genomic data from nematode species of medical and ...
Nicolas J Wheeler, Paul M Airs, Mostafa Zamanian   +2 more
doaj   +1 more source

Diagnosis of \u3cem\u3eSchistosoma mansoni\u3c/em\u3e without the Stool: Comparison of Three Diagnostic Tests to Detect \u3cem\u3eSchiostosoma mansoni\u3c/em\u3e Infection from Filtered Urine in Zambia [PDF]

, 2013
Diagnosis for intestinal Schistosoma mansoni lacks sensitivity and is arduous to conduct. The standard diagnostic tests, Kato-Katz (KK) and circulating cathodic antigen (CCA) both lack sensitivity and with KK, require obtaining, transporting, and ...
Lodh, Nilanjan, Mutengo, Mabel M., Mwansa, James C. L., Shiff, Clive J.   +3 more
core   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Comparison of four DNA extraction and three preservation protocols for the molecular detection and quantification of soil-transmitted helminths in stool [PDF]

, 2019
Background : A DNA extraction and preservation protocol that yields sufficient and qualitative DNA is pivotal for the success of any nucleic acid amplification test (NAAT), but it still poses a challenge for soil-transmitted helminths (STHs), including ...
Biruksew, Abdissa, Cools, Piet, Heda, Mio Ayana, Levecke, Bruno, Medebo, Daniel Dana, Mekonnen, Zeleke, Prichard, Roger, Rashwan, Nour, Verweij, Jaco J, Vlaminck, Johnny   +9 more
core   +1 more source