Results 81 to 90 of about 6,892 (155)

Parasitic helminth genomics. Filarial Genome Project.

Parasitology, 1999
The initiation of genome projects on helminths of medical importance promises to yield new drug targets and vaccine candidates in unprecedented numbers. In order to exploit this emerging data it is essential that the user community is aware of the scope and quality of data available, and that the genome projects provide analyses of the raw data to ...
M, Blaxter, M, Aslett, D, Guiliano, J, Daub   +3 more
openaire   +1 more source

Genomic and transcriptomic data production for helminths [PDF]

Protocol Exchange, 2018
Rahul Tyagi, John Martin, Makedonka Mitreva   +2 more
openaire   +2 more sources

Additional file 3: of Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths

, 2019
Figure S1. Multiple sequence alignment (MSA) of aaRSs 1) PRS of Plasmodium falciparum with PRSs of all studied human-infecting helminths showing conservation in HF binding residues, 2) CLD binding residues in Plasmodium falciparum aligned with KRSs of helminths, 3) binding residues in TRS of Cryptosporidium muris aligned with TRSs of helminths, 4 ...
Goel, Preeti, Parvez, Suhel, Sharma, Amit   +2 more
openaire   +1 more source

Additional file 2: of Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths

, 2019
Table S2. Domain description of all the aaRSs like proteins showing the presence of unusual domains. Unusual domains are mentioned in red. (PDF 99 kb)
Goel, Preeti, Parvez, Suhel, Sharma, Amit   +2 more
openaire   +1 more source

Additional file 1: of Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths

, 2019
Table S1. A list of all aaRSs like proteins from 27 studied human infecting helminths along with their gene IDs. (PDF 97 kb)
Goel, Preeti, Parvez, Suhel, Sharma, Amit   +2 more
openaire   +1 more source

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

International Journal for Parasitology: Drugs and Drug Resistance, 2018
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J. Marks, Aaron G. Maule   +8 more
doaj  

Differences in constitutive gene expression of cytochrome P450 enzymes and ATP-binding cassette transporter gene expression between a susceptible and a highly macrocyclic lactone-resistant Haemonchus contortus isolate in the absence of drug-inducible expression

Parasites & Vectors
Background Anthelmintic resistance in ruminants is a widespread problem that has a severe impact on productivity and animal welfare. The helminth Haemonchus contortus is generally considered the most important parasite in small ruminants due to its high ...
Natalie Jakobs, Sandro Andreotti, Sabrina Ramünke, Georg von Samson-Himmelstjerna, Jürgen Krücken   +4 more
doaj   +1 more source

Helminth genome analysis: the current status of the filarial and schistosome genome projects. Filarial Genome Project. Schistosome Genome Project.

Parasitology, 1999
Genome projects for the parasitic helminths Brugia malayi (a representative filarial nematode) and Schistosoma were initiated in 1995 by the World Health Organization with the ultimate objectives of identifying new vaccine candidates and drug targets and of developing low resolution genome maps. Because no genetic maps are available, and very few genes
S A, Williams, D A, Johnston
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Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population

SSM: Population Health, 2018
Racial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association ...
Thiago Magalhães da Silva, Rosemeire L. Fiaccone, Fernanda S.G. Kehdy, Eduardo Tarazona-Santos, Laura C. Rodrigues, Gustavo N.O. Costa, Camila A. Figueiredo, Neuza Maria Alcantara-Neves, Maurício L. Barreto   +8 more
doaj  

Improving Prediction of Helminth Aminoacyl‐tRNA Synthetases through Manual Analysis of Genomic Data

The FASEB Journal, 2021
Jevon Robinson, Seth Warner, Max Gjertson, David F. Wilson, Joseph Chihade, Alison Block   +5 more
openaire   +2 more sources