Results 81 to 90 of about 16,403 (216)

CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]

, 2020
Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam, Ebner, Friederike, Freund, Christian, Hartmann, Susanne, Midha, Ankur, Morrison, Eliot, Álvaro-Benito, Miguel   +6 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, Volume 599, Issue 23, Page 3444-3455, December 2025.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Parasitic helminth genomics. Filarial Genome Project.

Parasitology, 1999
The initiation of genome projects on helminths of medical importance promises to yield new drug targets and vaccine candidates in unprecedented numbers. In order to exploit this emerging data it is essential that the user community is aware of the scope and quality of data available, and that the genome projects provide analyses of the raw data to ...
M, Blaxter, M, Aslett, D, Guiliano, J, Daub   +3 more
openaire   +1 more source

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis [PDF]

, 2015
Extracellular vesicles (EVs) released by parasites have important roles in establishing and maintaining infection. Analysis of the soluble and vesicular secretions of adult Fasciola hepatica has established a definitive characterization of the total ...
Bernal, Dolores, Brennan, Gerard P, Cwiklinski, Krystyna, Dalton, John P, de la Torre-Escudero, Eduardo, Dufresne, Philippe J, Marcilla, Antonio, O'Neill, Sandra, Paterson, Steve, Robinson, Mark W, Tort, Jose, Trelis, Maria   +11 more
core   +1 more source

Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.

PLoS Genetics, 2008
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases.
Stephan Weidinger, Christian Gieger, Elke Rodriguez, Hansjörg Baurecht, Martin Mempel, Norman Klopp, Henning Gohlke, Stefan Wagenpfeil, Markus Ollert, Johannes Ring, Heidrun Behrendt, Joachim Heinrich, Natalija Novak, Thomas Bieber, Ursula Krämer, Dietrich Berdel, Andrea von Berg, Carl Peter Bauer, Olf Herbarth, Sibylle Koletzko, Holger Prokisch, Divya Mehta, Divya Mehta, Thomas Meitinger, Martin Depner, Erika von Mutius, Liming Liang, Miriam Moffatt, William Cookson, Michael Kabesch, H-Erich Wichmann, Thomas Illig   +31 more
doaj   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.
[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Targeting a highly repeated germline DNA sequence for improved real-time PCR-based detection of Ascaris infection in human stool.

PLoS Neglected Tropical Diseases, 2019
BackgroundWith the expansion of soil transmitted helminth (STH) intervention efforts and the corresponding decline in infection prevalence, there is an increased need for sensitive and specific STH diagnostic assays.
Nils Pilotte, Jacqueline R M A Maasch, Alice V Easton, Eric Dahlstrom, Thomas B Nutman, Steven A Williams   +5 more
doaj   +1 more source

Advances in the Gut‐Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential

Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.
ABSTRACT Background Bronchial asthma (hereafter referred to as asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and reversible airflow limitation. Recent advancements in the “gut‐lung” axis concept have elucidated the intricate immunometabolic crosstalk between the gastrointestinal tract
Ting Zheng, Yi Huang, Hongmei Yao
wiley   +1 more source

Schistosomes and snails: A molecular encounter [PDF]

, 2014
Copyright © 2014 Knight, Arican-Goktas, Ittiprasert, Odoemelam, Miller and Bridger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Arican-Goktas, HD, Bridger, JM, Ittiprasert, W, Knight, M, Miller, AN, Odoemelam, EC   +5 more
core   +3 more sources

Dysbiosis and Therapeutic Modulation of the Gut Microbiota in Multiple Sclerosis: A Narrative Review

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Multiple sclerosis (MS) is a persistent autoimmune disease that affects the central nervous system. The etiology of MS is complex, involving a variety of genetic and environmental factors. Mounting evidence suggests that dysbiosis significantly impacts the progression of MS mainly through its direct effects upon the immune ...
Mojtaba Memariani, Hamed Memariani
wiley   +1 more source