Results 211 to 220 of about 1,051,148 (367)
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs +13 morewiley +1 more sourceKnockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss
FEBS Open Bio, EarlyView.Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe +11 morewiley +1 more sourceMultiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Nature Genetics, 2018 R. Malik, G. Chauhan, M. Traylor, M. Sargurupremraj, Y. Okada, A. Mishra, L. Rutten-Jacobs, A. Giese, S. W. van der Laan, S. Gretarsdottir, C. Anderson, M. Chong, H. Adams, T. Ago, P. Almgren, P. Amouyel, H. Ay, Traci M. Bartz, O. Benavente, S. Bevan, G. Boncoraglio, Robert D. Brown, A. Butterworth, C. Carrera, C. Carty, D. Chasman, Wei-Min Chen, J. Cole, A. Correa, I. Cotlarciuc, Carlos Cruchaga, J. Danesh, P. D. de Bakker, A. Destefano, M. den Hoed, Qing Duan, S. Engelter, G. Falcone, R. Gottesman, R. Grewal, V. Gudnason, S. Gustafsson, J. Haessler, T. Harris, Ahamad Hassan, A. Havulinna, S. Heckbert, E. Holliday, G. Howard, F. Hsu, Hyacinth I. Hyacinth, M. Ikram, E. Ingelsson, M. Irvin, X. Jian, J. Jiménez-Conde, Julie A. Johnson, J. Jukema, M. Kanai, Keith L. Keene, B. Kissela, D. Kleindorfer, C. Kooperberg, M. Kubo, L. Lange, C. Langefeld, C. Langenberg, L. Launer, J. Lee, R. Lemmens, D. Leys, C. Lewis, Wei-Yu Lin, A. Lindgren, E. Lorentzen, P. Magnusson, J. Maguire, A. Manichaikul, P. McArdle, J. Meschia, B. Mitchell, T. Mosley, M. Nalls, T. Ninomiya, M. O’Donnell, B. Psaty, S. Pulit, Kristiina Rannikmäe, A. Reiner, K. Rexrode, K. Rice, S. Rich, P. Ridker, N. Rost, P. Rothwell, J. Rotter, T. Rundek, R. Sacco, S. Sakaue, M. Sale, V. Salomaa, B. Sapkota, R. Schmidt, C. Schmidt, U. Schminke, Pankaj Sharma, A. Słowik, C. Sudlow, C. Tanislav, T. Tatlisumak, K. Taylor, V. Thijs, G. Thorleifsson, U. Thorsteinsdóttir, S. Tiedt, S. Trompet, C. Tzourio, C. V. van Duijn, M. Walters, N. Wareham, S. Wassertheil-Smoller, James G. Wilson, K. Wiggins, Qiong Yang, S. Yusuf, J. Bis, T. Pastinen, A. Ruusalepp, E. Schadt, Simon Koplev, J. Björkegren, Veronica Codoni, M. Civelek, N. Smith, D. Trégouët, I. Christophersen, C. Roselli, S. Lubitz, P. Ellinor, E. Tai, J. Kooner, N. Kato, Jiang He, P. van der Harst, P. Elliott, J. Chambers, F. Takeuchi, Andrew D. Johnson, D. Sanghera, O. Melander, C. Jern, D. Strbian, I. Férnandez-Cadenas, W. Longstreth, A. Rolfs, J. Hata, D. Woo, J. Rosand, G. Paré, J. Hopewell, D. Saleheen, K. Stefánsson, B. Worrall, S. Kittner, S. Seshadri, M. Fornage, H. Markus, J. Howson, Y. Kamatani, S. Debette, M. Dichgans +170 moresemanticscholar +1 more sourceGenome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Nature Genetics, 2019 Hunna J. Watson, Z. Yilmaz, L. Thornton, Christopher Hübel, J. Coleman, Héléna A. Gaspar, J. Bryois, A. Hinney, V. Leppä, M. Mattheisen, S. Medland, S. Ripke, Shuyang Yao, P. Giusti-Rodríguez, K. Hanscombe, K. Purves, R. Adan, L. Alfredsson, T. Ando, O. Andreassen, J. Baker, W. Berrettini, Ilka Boehm, C. Boni, V. B. Perica, Katharina Buehren, R. Burghardt, M. Cassina, S. Cichon, M. Clementi, R. Cone, P. Courtet, S. Crow, J. Crowley, U. Danner, O. Davis, M. Zwaan, G. Dedoussis, D. Degortes, J. DeSocio, D. Dick, D. Dikeos, C. Dina, M. Dmitrzak-Węglarz, E. Docampo, L. Duncan, K. Egberts, S. Ehrlich, G. Escaramís, T. Esko, X. Estivill, A. Farmer, A. Favaro, F. Fernández-Aranda, M. Fichter, K. Fischer, M. Föcker, L. Foretova, A. Forstner, M. Forzan, C. Franklin, S. Gallinger, I. Giegling, J. Giuranna, F. Gonidakis, P. Gorwood, Monica Gratacos Mayora, S. Guillaume, Yiran Guo, H. Hakonarson, K. Hatzikotoulas, J. Hauser, J. Hebebrand, S. Helder, S. Herms, B. Herpertz-Dahlmann, W. Herzog, L. Huckins, J. Hudson, H. Imgart, H. Inoko, V. Janout, S. Jiménez-Murcia, A. Julià, G. Kalsi, D. Kaminská, J. Kaprio, L. Karhunen, A. Karwautz, M. Kas, J. Kennedy, A. Keski-Rahkonen, K. Kiezebrink, Y. Kim, L. Klareskog, K. Klump, G. Knudsen, M. C. Via, S. Hellard, R. Levitan, Dong Li, L. Lilenfeld, Bochao D. Lin, J. Lissowska, J. Luykx, P. Magistretti, M. Maj, Katrin Mannik, S. Marsal, C. Marshall, M. Mattingsdal, S. McDevitt, P. McGuffin, A. Metspalu, I. Meulenbelt, N. Micali, K. Mitchell, A. Monteleone, P. Monteleone, Melissa A. Munn-Chernoff, B. Nacmias, M. Navratilova, I. Ntalla, J. O'toole, R. Ophoff, L. Padyukov, A. Palotie, J. Pantel, H. Papežová, D. Pinto, R. Rabionet, Anu Raevuori, N. Ramoz, T. Reichborn-Kjennerud, V. Ricca, S. Ripatti, Franziska Ritschel, Marion E. Roberts, A. Rotondo, D. Rujescu, F. Rybakowski, P. Santonastaso, A. Scherag, S. Scherer, U. Schmidt, N. Schork, A. Schosser, J. Seitz, L. Šlachtová, P. Slagboom, M. S. '. Slof-Op 't Landt, A. Słopień, S. Sorbi, B. Świątkowska, J. Szatkiewicz, I. Tachmazidou, E. Tenconi, A. Tortorella, F. Tozzi, J. Treasure, A. Tsitsika, M. Tyszkiewicz-Nwafor, K. Tziouvas, A. Elburg, E. F. Furth, G. Wagner, E. Walton, E. Widén, E. Zeggini, S. Zerwas, S. Zipfel, A. Bergen, J. Boden, H. Brandt, Steven F. Crawford, K. Halmi, L. Horwood, Craig Johnson, A. Kaplan, W. Kaye, James E Mitchell, C. Olsen, J. Pearson, N. Pedersen, M. Strober, T. Werge, D. Whiteman, D. Woodside, G. Stuber, S. Gordon, J. Grove, A. Henders, A. Juréus, K. Kirk, J. Larsen, Richard Parker, L. Petersen, J. Jordan, M. Kennedy, G. Montgomery, T. Wade, A. Birgegård, P. Lichtenstein, C. Norring, M. Landén, N. Martin, P. Mortensen, P. Sullivan, G. Breen, C. Bulik, Anorexia Nervosa Genetics Initiative, Eating Disorder Working Group of the Psychiatric Genomics Consortium +211 moresemanticscholar +1 more sourceIdentifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao +13 morewiley +1 more sourceGenome-Wide Association Study of Immune Indices in Yaks. [PDF]
Animals (Basel)Yu D, Ma X, Huang C, Wang T, Zhang M, Feng F, Wu X, La Y, Guo X, Yan P, Zhang D, Liang C. +11 moreeuropepmc +1 more source
