Results 211 to 220 of about 674,070 (352)
Multi-ethnic genome-wide association study for atrial fibrillation
Nature Genetics, 2018 C. Roselli, M. Chaffin, L. Weng, S. Aeschbacher, G. Ahlberg, Christine M. Albert, P. Almgren, Á. Alonso, Christopher D. Anderson, Krishna G. Aragam, D. Arking, J. Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, J. Bis, Heather L. Bloom, E. Boerwinkle, Erwin Bottinger, J. Brody, H. Calkins, A. Campbell, Thomas P. Cappola, John Carlquist, D. Chasman, Lin Y Chen, Yii-DerIda Chen, Eue-Keun Choi, Seung Hoan Choi, IE Christophersen, M. Chung, John W. Cole, D. Conen, J. Cook, H. Crijns, Michael J. Cutler, S. Damrauer, Brian R. Daniels, D. Darbar, G. Delgado, Josh C. Denny, M. Dichgans, M. Dörr, E. Dudink, Samuel C. Dudley, Nada Esa, T. Esko, M. Eskola, D. Fatkin, S. Felix, I. Ford, Oscar H. Franco, B. Geelhoed, R. Grewal, V. Gudnason, Xiuqing Guo, N. Gupta, S. Gustafsson, Rebecca Gutmann, A. Hamsten, Tamara B. Harris, C. Hayward, S. Heckbert, J. Hernesniemi, L. Hocking, A. Hofman, A. Horimoto, Jie Huang, Paul L. Huang, J. Huffman, E. Ingelsson, E. G. Ipek, K. Ito, J. Jiménez-Conde, Renee Johnson, J. Jukema, S. Kääb, M. Kähönen, Y. Kamatani, J P Kane, A. Kastrati, S. Kathiresan, P. Katschnig-Winter, M. Kavousi, T. Kessler, B. Kietselaer, P. Kirchhof, M. Kleber, Stacey Knight, J. E. Krieger, M. Kubo, L. Launer, J. Laurikka, T. Lehtimäki, K. Leineweber, R. N. Lemaitre, Man Li, H. Lim, Henry J Lin, Honghuang Lin, L. Lind, Cecilia M. Lindgren, M. Lokki, Barry London, R. Loos, Siew-Kee Low, Yingchang Lu, L. Lyytikäinen, Peter W. Macfarlane, P. Magnusson, A. Mahajan, R. Malik, Alfredo J. Mansur, Gregory M. Marcus, L. Margolin, Kenneth B. Margulies, Winfried März, David D. McManus, O. Melander, S. Mohanty, Jay A. Montgomery, Michael P. Morley, Andrew P. Morris, M. Müller-Nurasyid, A. Natale, S. Nazarian, Benjamin Neumann, C. Newton‐Cheh, M. Niemeijer, K. Nikus, P. Nilsson, R. Noordam, Heidi Oellers, M. S. Olesen, M. Orho-Melander, S. Padmanabhan, H. Pak, Guillaume Paré, N. Pedersen, J. Pera, A. Pereira, D. Porteous, B. Psaty, Sara L. Pulit, C. Pullinger, Daniel J. Rader, L. Refsgaard, M. Ribasés, P. Ridker, M. Rienstra, L. Risch, Dan M. Roden, J. Rosand, Michael A. Rosenberg, Natalia S. Rost, Jerome I. Rotter, Samir Saba, R. Sandhu, R. Schnabel, K. Schramm, H. Schunkert, Claudia Schurman, Stuart A. Scott, I. Seppälä, C. Shaffer, Svati H. Shah, Alaa A. Shalaby, J. Shim, M. B. Shoemaker, J. Siland, J. Sinisalo, Moritz F. Sinner, A. Słowik, Albert V. Smith, Blair H. Smith, J. G. Smith, Jonathan D. Smith, Nicholas L. Smith, E. Soliman, N. Sotoodehnia, B. Stricker, A. Sun, Han Sun, J. Svendsen, Toshihiro Tanaka, K. Tanriverdi, K. Taylor, M. Teder-Laving, A. Teumer, S. Thériault, S. Trompet, N. Tucker, A. Tveit, A. Uitterlinden, P. van der Harst, I. V. van Gelder, D. V. Van Wagoner, N. Verweij, E. Vlachopoulou, U. Völker, Biqi Wang, P. Weeke, B. Weijs, Raul Weiss, S. Weiss, Q. Wells, K. Wiggins, Jorge A. Wong, Daniel Woo, B. Worrall, Pil‐Sung Yang, Jie Yao, Z. Yoneda, T. Zeller, Lingyao Zeng, S. Lubitz, K. Lunetta, P. Ellinor +217 moresemanticscholar +1 more sourceInterplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö +2 morewiley +1 more sourceGenome-wide association study reveals genetic architecture and evolution of human retinal pigmentation. [PDF]
Sci AdvYuan J, Zhang Y, Yao Y, Li S, Liang J, Dai W, Yang J, Liu M, Zhang Q, Zhou Y, Li J, Liu H, Chen ZJ, Myopia Associated Genetics and Intervention Consortium, MacGregor S, Qu J, Han X, Su J. +17 moreeuropepmc +1 more sourceOverexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada +7 morewiley +1 more sourceA genome-wide association study identifies the GPM6A locus associated with age at onset in ALS. [PDF]
Commun BiolNakamura R, Tohnai G, Atsuta N, Matsuda Y, Morimoto S, Ito D, Katsuno M, Izumi Y, Morita M, Iwata I, Yabe I, Nakazato T, Hattori N, Hirayama T, Kano O, Tamura A, Suzuki N, Aoki M, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Ishiura H, Bokuda K, Shimizu T, Ikeda Y, Hasegawa K, Tanaka F, Yokota T, Kanai K, Noto YI, Kaji R, Watanabe H, Konishi T, Hasegawa M, Fukaya H, Niwa JI, Doyu M, Okada Y, Nakamura S, Ozawa F, Okano H, Nakatochi M, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group. +48 moreeuropepmc +1 more sourceATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey +6 morewiley +1 more source
