Results 241 to 250 of about 674,070 (352)
FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma +3 morewiley +1 more sourceGenome-Wide Association Study of Varenicline-Aided Smoking Cessation. [PDF]
Nicotine Tob ResColey K, Wang Q, Packer R, John C, Abner E, Reis K, Estonian Biobank Research Team, Bedair KF, Srinivasan S, Paciga S, Hyde C, Free RC, Reeve NF, Shepherd DJ, Esko T, Palmer C, Pearson E, Malarstig A, Tobin MD, Batini C. +19 moreeuropepmc +1 more sourceGenome-wide association study of delay discounting in 134,935 individuals identifies novel loci and transdiagnostic associations across mental and physical health
Hayley HA Thorpe, Renata B. Cupertino, Shreya R. Pakala, Pierre Fontanillas, Mariela Jennings, Jane Yang, John J. Meredith, Tiffany A. Greenwood, Sevim B. Bianchi, Laura Vilar‐Ribó, Maria Niarchou, Sarah L. Elson, Trey Ideker, Lea K. Davis, James MacKillop, Harriet de Wit, Daniel E. Gustavson, Travis T. Mallard, Abraham A. Palmer, Sandra Sanchez‐Roige +19 moreopenalex +1 more sourceGenome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
Nature Neuroscience, 2019 J. Gelernter, Ning Sun, R. Polimanti, R. Pietrzak, D. Levey, J. Bryois, Q. Lu, Yiming Hu, Boyang Li, K. Radhakrishnan, M. Aslan, K. Cheung, Yuli Li, N. Rajeevan, F. Sayward, K. Harrington, Quan Chen, Kelly Cho, S. Pyarajan, P. Sullivan, Rachel M Quaden, Yunling Shi, Haley Hunter-Zinck, J. Gaziano, J. Concato, Hongyu Zhao, M. Stein, Department of Veterans Affairs Cooperative Studies Program an Program +27 moresemanticscholar +1 more sourceKLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul +6 morewiley +1 more sourceMycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci +7 morewiley +1 more sourceA genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform. [PDF]
Nat GenetSuhre K, Chen Q, Halama A, Mendez K, Dahlin A, Stephan N, Thareja G, Sarwath H, Guturu H, Dwaraka VB, Smith R, Batzoglou S, Schmidt F, Lasky-Su JA. +13 moreeuropepmc +1 more sourceTable 7_Normal hearing function genetics: have you heard all about it? An integrated approach of genome-wide association studies and transcriptome-wide association studies in three Italian cohorts.xlsx
Aurora Santin (16240550), Giulia Pianigiani (21384161), Alessandro Gialluisi (3413885), Alessandro Pecori (21384164), Beatrice Spedicati (16240547), Simona Costanzo (397282), Mariarosaria Persichillo (6101294), Francesca Bracone (12014342), Giuseppe Giovanni Nardone (15222149), Paola Tesolin (20920820), Stefania Lenarduzzi (13196688), Anna Morgan (687885), Amalia De Curtis (5663842), Wouter van der Valk (21384167), Francis Rousset (424375), Marta Roccio (118214), Heiko Locher (517913), Licia Iacoviello (285585), Maria Pina Concas (12643515), Giorgia Girotto (149894) +19 moreopenalex +1 more source
