Results 241 to 250 of about 1,051,148 (367)

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

open access: yesFEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić   +3 more
wiley   +1 more source

A genome-wide association study of imaging-defined atherosclerosis. [PDF]

open access: yesNat Commun
Gummesson A   +24 more
europepmc   +1 more source

Multi-ethnic genome-wide association study for atrial fibrillation

open access: yesNature Genetics, 2018
C. Roselli   +217 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

open access: yesFEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo   +11 more
wiley   +1 more source

Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors. [PDF]

open access: yesNat Commun
Pennance T   +13 more
europepmc   +1 more source

Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

open access: bronze, 2008
Pierandrea Muglia   +19 more
openalex   +1 more source

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study [PDF]

open access: green, 2008
Abbas Dehghan   +14 more
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu   +12 more
wiley   +1 more source

Multi-ancestry genome-wide association study of topiramate's effects on heavy alcohol use. [PDF]

open access: yesAlcohol Clin Exp Res (Hoboken)
Davis CN   +4 more
europepmc   +1 more source

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