Results 81 to 90 of about 2,754,601 (316)

dib-lab/genome-grist: v0.8.1

, 2022
What's Changed [MRG] split identifiers on whitespace, not just spaces. by @ctb in https://github.com/dib-lab/genome-grist/pull/150 [MRG] minor updates, incl. sourmash version updates.
Mohamed Abuelanin, Marisa Lim, Tessa Pierce Ward, C. Titus Brown   +3 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Mutational Frequencies of SARS-CoV-2 Genome during the Beginning Months of the Outbreak in USA

Pathogens, 2020
SARS-CoV-2 has spread very quickly from its first reported case on 19 January 2020 in the United Stated of America, leading WHO to declare pandemic by 11 March 2020.
Neha Kaushal, Yogita Gupta, Mehendi Goyal, Svetlana F. Khaiboullina, Manoj Baranwal, Subhash C. Verma   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Genome-wide distributed SNPs identified in the Black Bengal Goat versus the San Clemente genome

, 2019
Genome-wide SNPs were detected by aligning whole genome sequence of Black Bengal Goat with Clemente goat genome (GCA_001704415.1)
Gautam Kumar Deb (6325275), Md Panir Choudhury (6325276), Md Shamsul Alam Bhuiyan (6325268), Md Bazlur Rahman Mollah (4861135), Md Abdul Jalil (6325273), MAM Yahia Khandoker (6325271), Nure Hasni Desha (6325278)   +6 more
core   +1 more source

Analysis of high-identity segmental duplications in the grapevine genome [PDF]

, 2011
Background Segmental duplications (SDs) are blocks of genomic sequence of 1-200 kb that map to different loci in a genome and share a sequence identity > 90%.
VENTURA, MARIO, D'ADDABBO, PIETRO, Donato Antonacci, Mario Ventura, Ventura M, Ventura Mario, Giuliana Giannuzzi, Maurizio Martinelli, Marica Gasparro, Antonacci D, Gasparro Marica, Giannuzzi Giuliana, D'Addabbo P, D'Addabbo Pietro, Martinelli M, Martinelli Maurizio, Giannuzzi G, Pietro D'Addabbo, Carelli Francesco N, Francesco N Carelli, Antonacci Donato, Gasparro M, Carelli FN   +22 more
core   +2 more sources

Hawkeye: An interactive visual analytics tool for genome assemblies [PDF]

, 2007
Genome sequencing remains an inexact science, and genome sequences can contain significant errors if they are not carefully examined. Hawkeye is our new visual analytics tool for genome assemblies, designed to aid in identifying and correcting assembly ...
Steven L Salzberg, Salzberg, Steven L., Ben Shneiderman, Adam M Phillippy, Michael C Schatz, Salzberg, S. L., Phillippy, Adam M., Schatz, Michael C., Phillippy, A. M., Shneiderman, B., Schatz, M. C., Shneiderman, Ben   +11 more
core   +3 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source