Results 91 to 100 of about 294,348 (299)

Tumor irradiation induced immunogenic response: the impact of DNA damage induction and misrepair

Radiation Oncology
Focal tumor irradiation, a cornerstone of cancer therapy, has been increasingly recognized for its capacity to provoke systemic immunogenic responses that extend beyond localized tumor control.
Qi Liu, Xiaoran Shi, Nilupaier Tayier, Lin Ma   +3 more
doaj   +1 more source

Decoding protein methylation function with thermal stability analysis

Nature Communications, 2023
Protein methylation is an important modification beyond epigenetics. However, systems analyses of protein methylation lag behind compared to other modifications.
Cristina Sayago, Jana Sánchez-Wandelmer, Fernando García, Begoña Hurtado, Vanesa Lafarga, Patricia Prieto, Eduardo Zarzuela, Pilar Ximénez-Embún, Sagrario Ortega, Diego Megías, Oscar Fernández-Capetillo, Marcos Malumbres, Javier Munoz   +12 more
doaj   +1 more source

A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]

, 2019
Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G, Eskin, Eleazar, Graeber, Thomas G, Yao, Douglas W   +3 more
core  

Predictive genomics: A cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing data

, 2014
We discuss a cancer hallmark network framework for modelling genome-sequencing data to predict cancer clonal evolution and associated clinical phenotypes.
Masoudi-Nejad, Ali, Mcgee, Shauna, Milanese, Jean-Sébastien, O'Connor, Maureen, Wang, Edwin, Zaman, Naif   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Genome Instability [PDF]

Cell, 2011
Maintaining genomic stability in the face of replication and recombination requires a huge variety of different damage response proteins. A cell's ability to decide when and where to deploy this DNA repair kit is critical to prevent tumor development. This issue's Select highlights recent studies that help to explain how these difficult decisions are ...
openaire   +2 more sources

WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

Cell Reports
Summary: The MRE11-RAD50-NBS1 (MRN) complex is fundamental for detecting and repairing DNA double-strand breaks (DSBs), thereby safeguarding genome integrity.
Ya-Fei Lu, Huangqi Tang, Longjiang Di, Yerkezhan Yerkinkazhina, Jiajie Su, Ming Tang, Jinqin Qian, Rongsheng Zeng, Yuxin Shu, Xingkai He, Hui Yang, Jun Zhang, Yuan Tian, Qian Zhu, Luyao Zhang, Yongqing Wang, Dongchun Ni, Xin-Hai Pei, Ying Zhao, Chung-Hang Leung, Xiaopeng Lu, Wei-Guo Zhu   +21 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

SLC30 (ZnT) and SLC39 (ZIP) zinc transporter families: from gatekeepers of zinc homeostasis to promoters of tumorigenesis and targets for clinical therapy

Frontiers in Immunology
Zinc is a trace element that plays important functions in gene expression, enzymatic activity and cellular signaling. Cellular zinc homeostasis is tightly regulated by two solute carrier families: SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, zrt- and ...
Yuqiao Zhou, Yuqiao Zhou, Guangfa Huang, Mengling Liu, Minghui Zhang, Minghui Zhang, Bowen Wu, Bowen Wu, Jinke Gu   +8 more
doaj   +1 more source