Results 171 to 180 of about 294,348 (299)

Genome instability in mammalian embryos implications for genome editing, development, and evolution. [PDF]

Curr Opin Genet Dev
Liu X, Xu S, Egli D.
europepmc   +1 more source

Common fragile sites. Structure, replication and their role in chromosome instabiity [PDF]

, 2011
BOSCO, NAZARIO
core  

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Reprogramming tumor immunity through APOBEC3s-mediated mutagenesis: from genome instability to immune checkpoint interactions. [PDF]

Front Immunol
Li Q, Wan W, Zhu Z, Lin X, Wang F, Li M, Guo H, Yang Y.   +7 more
europepmc   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

High-throughput mapping of spontaneous mitotic crossover and genome instability events with sci-L3-Strand-seq. [PDF]

Nucleic Acids Res
Chovanec P, Ridgley T, Yin Y.
europepmc   +1 more source

Editorial: Impact of genome instability on human health. [PDF]

Front Mol Biosci, 2023
Ray S, Chakrabarty S, Chaudhuri AR.
europepmc   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Short Inverted Repeats as Mutational Hotspots and Putative Drivers of Genome Instability in Osteosarcoma. [PDF]

Genes (Basel)
Li M, Liang C.
europepmc   +1 more source

Genome instability footprint under rapamycin and hydroxyurea treatments. [PDF]

PLoS Genet, 2023
Li J, Stenberg S, Yue JX, Mikhalev E, Thompson D, Warringer J, Liti G.   +6 more
europepmc   +1 more source