Results 341 to 350 of about 1,743,586 (380)

Lignin bioconversion based on genome mining for ligninolytic genes in Erwinia billingiae QL-Z3. [PDF]

Biotechnol Biofuels Bioprod
Zhao S, Deng D, Wan T, Feng J, Deng L, Tian Q, Wang J, Aiman UE, Mukhaddi B, Hu X, Chen S, Qiu L, Huang L, Wei Y.   +13 more
europepmc   +1 more source

Secondary metabolism of Streptomyces ambofaciens : genome mining and study of the gene cluster involved in sphydrofuran biosynthesis

, 2015
Drago Haas
openalex   +1 more source

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

PROTEOMICS, EarlyView.
Paul Perco, Matthias Ley, Kinga Kęska‐Izworska, Dorota Wojenska, Enrico Bono, Samuel M. Walter, Lucas Fillinger, Klaus Kratochwill   +7 more
wiley   +1 more source

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A Combination of Genome Mining with an OSMAC Approach Facilitates the Discovery of and Contributions to the Biosynthesis of Melleolides from the Basidiomycete Armillaria tabescens.

Journal of Agricultural and Food Chemistry, 2022
Genome mining revealed that the genomes of basidiomycetes may include a considerable number of biosynthetic gene clusters (BGCs), yet numerous clusters remain unidentified.
Tao Zhang, Guowei Cai, Xiaoting Rong, Yuquan Wang, Kaikai Gong, Wancang Liu, Lü-ya Wang, Xu Pang, Liyan Yu   +8 more
semanticscholar   +1 more source

Mining the Pseudomonas Genome [PDF]

, 2014
Pseudomonas species were targeted early for genomic studies since they were noted for their diverse metabolic capacity, ability to inhabit a wide range of environments and hosts, and include notable human and agriculturally relevant pathogens. As more genomes are sequenced, the power of genome-scale analyses are increasing and a wide range of analyses ...
Fiona S. L. Brinkman, Geoffrey L. Winsor
openaire   +2 more sources

Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis.

Journal of Natural Products, 2022
Genome mining and biocatalytic modification of chemical structures are critical methods to develop new antibiotics. In this study, eight new fasamycins (3, 4, 6, and 8-12) along with five known analogues (1, 2, 5, 7, and 13) were obtained by the ...
Kai Jiang, Xiaoli Yan, Z. Deng, Chun Lei, X. Qu   +4 more
semanticscholar   +1 more source

Griseocazines: Neuroprotective Multiprenylated Cyclodipeptides Identified through Targeted Genome Mining.

Organic Letters, 2022
Prenylation can impart pharmacological advantages to bioactive compounds. Global genome mining for prenylated cyclodipeptides identified a gczABC BGC from Streptomyces griseocarneus 132 containing a cyclodipeptide synthase and two prenyltransferase genes.
J. Malit, Chuanhai Wu, Xueying Tian, Wenchao Liu, Duli Huang, H. Sung, Ling-Li Liu, Ian D. Williams, P. Qian   +8 more
semanticscholar   +1 more source

Genome Mining Reveals a Multiproduct Sesterterpenoid Biosynthetic Gene Cluster in Aspergillus ustus.

Organic Letters, 2021
Genome mining of Aspergillus ustus 094102 enabled the discovery of a multiproduct bifunctional terpene synthase (BTS), AuAS. Heterologous expression of AuAS led to the discovery of five new sesterterpenes, and coexpression of the upstream CYP450 ...
Jingjing Guo, You-sheng Cai, Fangcai Cheng, Chenjie Yang, Wenqi Zhang, Wulin Yu, Jingjing Yan, Z. Deng, K. Hong   +8 more
semanticscholar   +1 more source

Peer Reviewed: Mining Genomes with MS

Analytical Chemistry, 1996
Searching protein and nucleotide databases with MS data allows accurate identification of amino acid ...
John R. Yates, null III, Ashley L. McCormack, Jimmy Eng   +3 more
openaire   +3 more sources

Global Genome Mining Reveals a Cytochrome P450-Catalyzed Cyclization of Crownlike Cyclodipeptides with Neuroprotective Activity.

Organic Letters, 2021
We conducted global genome mining of 162,672 bacterial genomes and identified 829 cyclodipeptide (CDP) biosynthesis gene clusters (BGC) containing a cytochrome P450 gene.
J. Malit, Wenchao Liu, Aifang Cheng, S. Saha, Ling-Li Liu, P. Qian   +5 more
semanticscholar   +1 more source