Results 351 to 360 of about 1,743,586 (380)

The confluence of big data and evolutionary genome mining for the discovery of natural products.

Natural product reports (Print), 2021
This review covers literature between 2003-2021The development and application of genome mining tools has given rise to ever-growing genetic and chemical databases and propelled natural products research into the modern age of Big Data.
M. Chevrette, Athina Gavrilidou, Shrikant S. Mantri, Nelly Sélem-Mojica, N. Ziemert, F. Barona-Gómez   +5 more
semanticscholar   +1 more source

Combining NMR-Based Metabolic Profiling and Genome Mining for the Accelerated Discovery of Archangiumide, an Allenic Macrolide from the Myxobacterium Archangium violaceum SDU8.

Organic Letters, 2021
An unprecedented 19-membered allenic macrolide archangiumide (1) was discovered from the myxobacterium Archangium violaceum SDU8 by integrating NMR-based metabolic profiling and genome mining.
Jia-Qi Hu, Jing-Jing Wang, Yuelan Li, Li Zhuo, A. Zhang, H. Sui, Xiao-Ju Li, Tao Shen, Yizhen Yin, Zhi-hong Wu, Wei Hu, Yue-zhong Li, Changsheng Wu   +12 more
semanticscholar   +1 more source

Mining the genome

IEEE Spectrum, 2002
Having tackled the human genome, Celera's Gene Myers is now advancing on proteins and drug development. This article discusses Myers' work on developing computational biology for the human genome project. The further development of computational biology for the pharmaceutical industry is also discussed.
openaire   +2 more sources

Mining the genomes of exceptional responders

Nature Reviews Cancer, 2014
The National Cancer Institute of the United States recently announced a major new initiative in understanding the genomes or, more broadly, the molecular phenotypes of exceptional responders. What can we expect to learn from exceptional responders? What are the potential benefits, and how do we approach studying them?
Chang, David K., Grimmond, Sean M., Evans, T. R. Jeffry, Biankin, Andrew V.   +3 more
openaire   +4 more sources

Mining microsatellites in eukaryotic genomes

Trends in Biotechnology, 2007
During recent decades, microsatellites have become the most popular source of genetic markers. More recently, the availability of enormous sequence data for a large number of eukaryotic genomes has accelerated research aimed at understanding the origin and functions of microsatellites and searching for new applications.
Prakash C. Sharma, Atul Grover, Günter Kahl   +2 more
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Mining the Genome for Drugs

Science, 1999
SCIENCE AND BUSINESSPartly because of its early association with The Institute for Genomic Research, a company started by researchers who had devised an efficient way of finding genes, Human Genome Sciences Inc. of Rockville, Maryland, has a leg up on other biotech companies in current efforts to use modern genomics to find and develop new protein ...
openaire   +2 more sources

Data mining in genomics and proteomics

Artificial Intelligence in Medicine, 2004
Studies in genomics and proteomics are contributing to major improvements in the field of medicine.
Larrañaga Múgica, Pedro María, Menasalvas Ruiz, Ernestina, Peña Sánchez, José María, Robles Forcada, Víctor   +3 more
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Bioinformatics — Mining the genome for information [PDF]

Frontiers of Electrical and Electronic Engineering in China, 2010
Since the launching of the human genome sequencing project in the 1990s, genomic research has already achieved definite results. At the beginning of the present century, the complete genomes of several model organisms have already been sequenced, including a number of prokaryote microorganisms and the eukaryotes yeast (Saccharomyces cerevisiae ...
Runsheng Chen, Geir Skogerbø
openaire   +1 more source

Genome Mining Reveals High Topological Diversity of ω-Ester Containing Peptides and Divergent Evolution of ATP-Grasp Macrocyclases.

Journal of the American Chemical Society, 2020
ω-Ester containing peptides (OEPs) are a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) containing intramolecular ω-ester or ω-amide bonds.
Hyunbin Lee, Mingyu Choi, Jung-Un Park, Heejin Roh, Seokhee Kim   +4 more
semanticscholar   +1 more source

Functional genome mining reveals a novel class V lanthipeptide containing a D-amino acid introduced by an F420H2-dependent reductase.

Angewandte Chemie, 2020
Lantibiotics are a type of ribosomally synthesized and post-translationally modified peptides (termed lanthipeptides) with often potent antimicrobial activity.
Min Xu, Fei Zhang, Zhuo Cheng, G. Bashiri, Jing Wang, Jiali Hong, Yemin Wang, Lijun Xu, Xuefei Chen, Sheng-Xiong Huang, Shuangjun Lin, Z. Deng, M. Tao   +12 more
semanticscholar   +1 more source