Results 161 to 170 of about 5,189,630 (339)

Simulation and Quantitative Analysis of Spatial Centromere Distribution Patterns

Cells
A prominent feature of eukaryotic chromosomes are centromeres, which are specialized regions of repetitive DNA required for faithful chromosome segregation during cell division.
Adib Keikhosravi, Krishnendu Guin, Gianluca Pegoraro, Tom Misteli   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

RNA Pol II-based regulations of chromosome folding

Cell Genomics
Summary: The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation.
Christophe Chapard, Nathalie Bastié, Axel Cournac, Laura Chaptal, Henri Mboumba, Sophie Queille, Agnes Thierry, Olivier Gadal, Armelle Lengronne, Romain Koszul, Frédéric Beckouët   +10 more
doaj   +1 more source

Engineering 3D genome organization [PDF]

Cell Research, 2018
Xiaowen Lyu, Victor G. Corces
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Editorial: Chromatin architecture in gene regulation and disease

Frontiers in Genetics, 2023
Xiang Wang
doaj   +1 more source

A diverse satellite DNA repertoire in Limnoperna fortunei: insights into genome structure and chromosomal organization

Frontiers in Molecular Biosciences
BackgroundThe Golden Mussel, Limnoperna fortunei, represents one of the most successful aquatic invaders in South America, causing significant ecological and economic impacts.
Jonathan Pena Castro, Tiago Marafiga Degrandi, Allan Oliveira Leal, Augusto Luiz Ferreira Júnior, Mara Cristina de Almeida, Roberto Ferreira Artoni, Roberto Ferreira Artoni   +6 more
doaj   +1 more source

Coffea Genome Organization and Evolution

, 2015
Abstract A recently proposed delimitation of the genus Coffea has raised new questions of geographical distribution, its evolutionary history, and mechanisms of its speciation. Global chromosome morphology and uniform C-banding patterns argue for a unique and common Coffea genome.
Hamon, Perla, Hamon, Serge, Razafinarivo, Norosoa J., Guyot, Romain, Siljak-Yakovlev, S., Couturon, Emmanuel, Crouzillat, D., Rigoreau, M., Akaffou, S., Rakotomalala, J.J., Kochko, Alexandre de   +10 more
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source