Results 171 to 180 of about 11,389,397 (311)

The Human Genome Project [PDF]

Journal of the Royal Society of Medicine, 2005
openaire   +2 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The clinical utility of genome sequencing is multi-dimensional: experience from the Hong Kong Genome Project. [PDF]

Commun Med (Lond)
Chu ATW, Chung CCY, Luk HM, Cheng SSW, Hayeems R, Luca S, Chung BHY.   +6 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The Karnataka Individual Genome Project expands the human reference landscape to include South Asia. [PDF]

HGG Adv
Ganesh A, Mhatre A, Chindarkar Y, Goswami M, Mishra P, Sharma A, Kalpande M, Ravindran F, Srinivasan S, Choudhary B.   +9 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Moroccan genome project: genomic insight into a North African population. [PDF]

Commun Biol
El Fahime E, Kartti S, Chemao-Elfihri MW, Festali R, Hakmi M, Ibrahimi A, Boutayeb S, Belyamani L.   +7 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Race and the Human Genome

, 1999
review: PLAIN TALK ABOUT THE HUMAN GENOME PROJECT: A TUSKEGEE UNIVERSITY CONFERENCE ON ITS PROMISE AND PERILS ...
Fleissner, Erwin
core  

The Ecological Genome Project and the Promises of Ecogenomics for Society: Realising a Shared Vision as One Health. [PDF]

Bioethics
Capps B, Chadwick R, Joly Y, Lajaunie C, Hauptmannova I, Mackenzie S, Mulvihill JJ, Mumford E, Rasmussen SA, Sanghavi K, Thaldar DW, Yeates J, Quinzin MC, Lederman Z.   +13 more
europepmc   +1 more source