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Development of a tetracycline-inducible programmed ribosomal frameshifting platform for sensitive regulation of mammalian gene expression. [PDF]
Nucleic Acids ResKöse S +5 more
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Synonymous Virus Genome Recoding as a Tool to Impact Viral Fitness
Trends in Microbiology, 2016Synthetic genome recoding is a novel method of generating viruses with altered phenotypes, whereby many synonymous mutations are introduced into the protein coding region of the virus genome without altering the encoded proteins. Virus genome recoding with large numbers of slightly deleterious mutations has produced attenuated forms of several RNA ...
MIGUEL Angel Martinez +2 more
exaly +4 more sources
Synthetic genome with recoding
Science China Life Sciences, 2019Bin Jia +4 more
semanticscholar +3 more sources
Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis, 2021
Rove beetles (Staphylinidae) and allied families constitute a huge radiation of Coleoptera, but basal relationships in this group remain controversial. In this study, we newly sequenced eight mitogenomes of representatives of Staphylinidae by using next ...
Nan Song, Qing Zhai, Yaling Zhang
semanticscholar +1 more source
Rove beetles (Staphylinidae) and allied families constitute a huge radiation of Coleoptera, but basal relationships in this group remain controversial. In this study, we newly sequenced eight mitogenomes of representatives of Staphylinidae by using next ...
Nan Song, Qing Zhai, Yaling Zhang
semanticscholar +1 more source
Codon Effect on the Entire Genome Based upon Genome-Wide Recoded Escherichia coli
2021 IEEE 9th International Conference on Bioinformatics and Computational Biology (ICBCB), 2021Synonymous codon mutation can influence transcription and translation through gene expression. Researchers have studied how altering codons is linked to expression. However, they did not investigate the correlations at a whole genome level. We classified 1090 genes encoding proteins and analyzed their sequence properties in both strains of Escherichia ...
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Journal of Virology
Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein-coding RNA.
J. V. van Bree +10 more
semanticscholar +1 more source
Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein-coding RNA.
J. V. van Bree +10 more
semanticscholar +1 more source
ACS Synthetic Biology, 2016
Small synthetic fluorophores are in many ways superior to fluorescent proteins as labels for imaging. A major challenge is to use them for a protein-specific labeling in living cells. Here, we report on our use of noncanonical amino acids that are genetically encoded via the pyrrolysyl-tRNA/pyrrolysyl-RNA synthetase pair at artificially introduced TAG ...
Kipper K +6 more
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Small synthetic fluorophores are in many ways superior to fluorescent proteins as labels for imaging. A major challenge is to use them for a protein-specific labeling in living cells. Here, we report on our use of noncanonical amino acids that are genetically encoded via the pyrrolysyl-tRNA/pyrrolysyl-RNA synthetase pair at artificially introduced TAG ...
Kipper K +6 more
openaire +3 more sources
Genomically recoded organisms: redefining and safeguarding biological systems
Trends in BiotechnologyIn a recent report, Grome et al. describe a genomically recoded Escherichia coli strain with a 62-codon genome and a single stop codon. This and other genomically recoded organisms (GROs), engineered with modified genetic vocabularies, enable the creation of novel proteins and biomaterials, while ensuring the safety and viability of GRO-based ...
openaire +2 more sources