Results 291 to 300 of about 1,880,451 (340)
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Science, 1996
I have learned that the U.S. National Institutes of Health (NIH) is to support a program to sequence the genome of Microbacterium tuberculosis . While this information is desperately needed to advance studies that could provide essential clues to the pathogenesis and effective treatment of tuberculosis, I am dismayed and disappointed by the decision ...
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I have learned that the U.S. National Institutes of Health (NIH) is to support a program to sequence the genome of Microbacterium tuberculosis . While this information is desperately needed to advance studies that could provide essential clues to the pathogenesis and effective treatment of tuberculosis, I am dismayed and disappointed by the decision ...
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Whole-Exome/Genome Sequencing and Genomics
Pediatrics, 2013As medical genetics has progressed from a descriptive entity to one focused on the functional relationship between genes and clinical disorders, emphasis has been placed on genomics. Genomics, a subelement of genetics, is the study of the genome, the sum total of all the genes of an organism.
Wayne W, Grody +2 more
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Nature Reviews Genetics, 2001
Genome sequencing projects have been undertaken in one of three ways: in a purpose-built and professionally staffed genome centre, by a small number of traditional research laboratories or by an extensive network of traditional research laboratories that are linked by the Internet.
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Genome sequencing projects have been undertaken in one of three ways: in a purpose-built and professionally staffed genome centre, by a small number of traditional research laboratories or by an extensive network of traditional research laboratories that are linked by the Internet.
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Nature Medicine, 1995
Full analysis of two microbial genomes points towards complete catalogues of virulence and disease genes while tracking the course of evolution.
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Full analysis of two microbial genomes points towards complete catalogues of virulence and disease genes while tracking the course of evolution.
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Gene, 2012
The existence of fractal sets of DNA sequences have long been suspected on the basis of statistical analyses of genome data. In this article we identify for the first time explicitly the GA-sequences as a class of fractal genomic sequences that are easy to recognize and to extract, and are scattered densely throughout the chromosomes of a large number ...
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The existence of fractal sets of DNA sequences have long been suspected on the basis of statistical analyses of genome data. In this article we identify for the first time explicitly the GA-sequences as a class of fractal genomic sequences that are easy to recognize and to extract, and are scattered densely throughout the chromosomes of a large number ...
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2021
Next-generation sequencing (NGS) is a rapidly developing technology with a wide range of applications in biological sciences. Historically, DNA sequencing has evolved from the first to the second and third generation in less than 50 years. This chapter aims to provide guidance for designing NGS studies, performing NGS experiments and analysing NGS data,
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Next-generation sequencing (NGS) is a rapidly developing technology with a wide range of applications in biological sciences. Historically, DNA sequencing has evolved from the first to the second and third generation in less than 50 years. This chapter aims to provide guidance for designing NGS studies, performing NGS experiments and analysing NGS data,
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1988
The human genome contains 3 billion base pairs of DNA, sufficient to encode 100,000 to 300,000 genes. Since the number of genes that make up a human being is not known, this estimate is based upon a national average size for a mammalian gene. If the average gene is 30,000 bases long, there will be about 100,000 genes.
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The human genome contains 3 billion base pairs of DNA, sufficient to encode 100,000 to 300,000 genes. Since the number of genes that make up a human being is not known, this estimate is based upon a national average size for a mammalian gene. If the average gene is 30,000 bases long, there will be about 100,000 genes.
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Genome Sequencing and Genomics
2014This chapter explores issues related to Legionella genomics. A critical breakthrough in this area recently occurred with the determination of the genome sequences of three clinical, serogroup 1 isolates of Legionella pneumophila subsp. pneumophila. The three strains are L. pneumophila Paris, Lens and Philadelphia-1.
Carmen Buchrieser +3 more
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Interpreting Whole-Genome Sequencing
JAMA, 2014We believe that the report of the yield and interpretability of clinical whole-genome sequencing by Dr Dewey and colleagues1 is unduly pessimistic about the present and future efficacy of this molecular genetic technology in clinical medicine. Their experience of low coverage of key disease genes, poor nucleotide-calling reproducibility, low diagnostic
Wayne W, Grody +2 more
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Genome sequencing: Illuminating the sunflower genome
Nature Plants, 2017A high-quality sunflower genome provides insight into Asterid genome evolution. Moreover, integrative analyses based on quantitative genetics, expression and diversity data uncover the gene networks and candidate genes for oil metabolism and flowering time, two important agronomic traits for sunflowers.
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