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Genome Sequencing and Assembly
2011Decoding the genome sequence is becoming a fundamental tool for molecular, genetic, and genomic studies. This chapter reviews the history of DNA sequencing and technical principles of different sequencing platforms, and compares the strengths and weaknesses of different techniques for high-throughput genome sequencing applications are compared. It also
Manfred Grabherr +2 more
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Science, 1996
I have learned that the U.S. National Institutes of Health (NIH) is to support a program to sequence the genome of Microbacterium tuberculosis . While this information is desperately needed to advance studies that could provide essential clues to the pathogenesis and effective treatment of tuberculosis, I am dismayed and disappointed by the decision ...
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I have learned that the U.S. National Institutes of Health (NIH) is to support a program to sequence the genome of Microbacterium tuberculosis . While this information is desperately needed to advance studies that could provide essential clues to the pathogenesis and effective treatment of tuberculosis, I am dismayed and disappointed by the decision ...
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2009
For over 30 yr, the Sanger method has been the standard for DNA sequencing. Instruments have been developed and improved over time to increase throughput, but they always relied on the same technology. Today, we are facing a revolution in DNA sequencing with many drastically different platforms that have become or will soon become available on the ...
Hervé Tettelin, T. Feldblyum
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For over 30 yr, the Sanger method has been the standard for DNA sequencing. Instruments have been developed and improved over time to increase throughput, but they always relied on the same technology. Today, we are facing a revolution in DNA sequencing with many drastically different platforms that have become or will soon become available on the ...
Hervé Tettelin, T. Feldblyum
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2014
The current Lotus japonicus reference genome sequence is based on a hybrid assembly of Sanger TAC/BAC, Sanger shotgun and Illumina shotgun sequencing data generated from the Miyakojima-MG20 accession. It covers nearly all expressed L. japonicus genes and has been annotated mainly based on transcriptional evidence.
Sato, Shusei, Andersen, Stig Uggerhøj
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The current Lotus japonicus reference genome sequence is based on a hybrid assembly of Sanger TAC/BAC, Sanger shotgun and Illumina shotgun sequencing data generated from the Miyakojima-MG20 accession. It covers nearly all expressed L. japonicus genes and has been annotated mainly based on transcriptional evidence.
Sato, Shusei, Andersen, Stig Uggerhøj
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, 1988 The human genome contains 3 billion base pairs of DNA, sufficient to encode 100,000 to 300,000 genes. Since the number of genes that make up a human being is not known, this estimate is based upon a national average size for a mammalian gene. If the average gene is 30,000 bases long, there will be about 100,000 genes.
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2010
Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. We review methodologies for whole genome sequencing.
Pauline C. Ng, Ewen F. Kirkness
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Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. We review methodologies for whole genome sequencing.
Pauline C. Ng, Ewen F. Kirkness
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Nature Medicine, 1995
Full analysis of two microbial genomes points towards complete catalogues of virulence and disease genes while tracking the course of evolution.
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Full analysis of two microbial genomes points towards complete catalogues of virulence and disease genes while tracking the course of evolution.
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Whole-Exome/Genome Sequencing and Genomics
Pediatrics, 2013As medical genetics has progressed from a descriptive entity to one focused on the functional relationship between genes and clinical disorders, emphasis has been placed on genomics. Genomics, a subelement of genetics, is the study of the genome, the sum total of all the genes of an organism.
Barry H. Thompson +2 more
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Genome Sequencing and Annotation
2003The availability of complete microbial genome sequences enormously facilitates experimental molecular investigations of the respective organisms by providing complete lists of genes, their genetic contexts, and their predicted functions. This can be used in a number of ways to focus studies on bacterial pathogenesis and also vaccine development (1,2 ...
Alex C. Jeffries +2 more
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Gene, 2012
The existence of fractal sets of DNA sequences have long been suspected on the basis of statistical analyses of genome data. In this article we identify for the first time explicitly the GA-sequences as a class of fractal genomic sequences that are easy to recognize and to extract, and are scattered densely throughout the chromosomes of a large number ...
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The existence of fractal sets of DNA sequences have long been suspected on the basis of statistical analyses of genome data. In this article we identify for the first time explicitly the GA-sequences as a class of fractal genomic sequences that are easy to recognize and to extract, and are scattered densely throughout the chromosomes of a large number ...
openaire +3 more sources