Results 181 to 190 of about 733,963 (352)

A yeast gene, MGS1 , encoding a DNA-dependent AAA ⁺ ATPase is required to maintain genome stability

, 2001
Takashi Hishida, Hiroshi Iwasaki, Takayuki Ohno, Takashi Morishita, Hideo Shinagawa   +4 more
openalex   +2 more sources

Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability [PDF]

, 2018
Thomas van Emden, Marta Forn, Ignasi Forné, Zsuzsa Sarkadi, Matías Capella, Lucía Martín Caballero, Sabine Fischer‐Burkart, Cornelia Brönner, Marco Simonetta, David P. Toczyski, Mario Halić, Axel Imhof, Sigurd Braun   +12 more
openalex   +1 more source

Downregulation of tRF-Cys-GCA-029 by hyperglycemia promotes tumorigenesis and glycolysis of diabetic breast cancer through upregulating PRKCG translation

Breast Cancer Research
Background Diabetes mellitus (DM) affects up to one-third of breast cancer (BC) patients. Patients with co-existing BC and DM (BC-DM) have worsened BC prognosis.
Yongyi Huang, Cheng Chen, Yang Liu, Binbin Tan, Qin Xiang, Qianqian Chen, Yiling Wang, Wenhan Yang, Jingsong He, Duanyang Zhou, Yuting Wang, Kaiping Gao, Duo Zheng, Rihong Zhai   +13 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The Transcription Elongation Factor Bur1-Bur2 Interacts with Replication Protein A and Maintains Genome Stability during Replication Stress [PDF]

, 2010
Emanuel Clausing, Andreas Mayer, Sittinan Chanarat, Bárbara Müller, Susanne M. Germann, Patrick Cramer, Michael Lisby, Katja Sträßer   +7 more
openalex   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Deletion of Open Reading Frame UL26 from the Human Cytomegalovirus Genome Results in Reduced Viral Growth, Which Involves Impaired Stability of Viral Particles

, 2006
Kerstin Lorz, Heike Hofmann, Anja Berndt, Nina Tavalai, Regina Mueller, Ursula Schlötzer‐Schrehardt, Thomas Stamminger   +6 more
openalex   +1 more source

Author Correction: Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy

Nature Communications, 2023
Najmeh Soltanmohammadi, Siyao Wang, Björn Schumacher   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Understanding the role of ascorbic acid and GDP-mannose pyrophosphorylase affecting ammonium sensitivity, genome stability and flowering time in Arabidopsis thaliana

, 2011
Chase F. Kempinski
openalex   +2 more sources