Results 191 to 200 of about 26,875,751 (309)

Cancer genomic data systems in precision oncology: from integration to clinical implementation. [PDF]

EBioMedicine
Torrents D, Hofmann O, Cranston KA, Casolino R, Biankin AV, Cardona AF, Grossman RL, Johns A, Lawler M, Lehmann KV, Garcia RM, Mulder N, Osterman T, Rebbeck T, Rotimi S, Sondka Z, Sweeney S, Volchenboum S, Wagner A, Wu J, Yoshino T, Courtot M, Stein L.   +22 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

SNPio: a Python interface for population genomic data processing. [PDF]

BMC Bioinformatics
Martin BT, Monaco DR, Sharabi N, Mussmann SM, Chafin TK.   +4 more
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Making Genomic Data Actionable in Electronic Health Records: Practical Viewpoint on Standards, Governance, and Implementation. [PDF]

JMIR Med Inform
Menelaou S, Schiza EC, Tomazou M, Neocleous A, Oulas A, Pipis M, Menikou A, Theodosiou A, Papaioannou M, Sismani C, Kyprianou T, Spyrou GM, Schizas CN.   +12 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Response to comment on "Using genomic data and machine learning to predict antibiotic resistance: A tutorial paper". [PDF]

PLoS Comput Biol
Moctezuma Tan L, Orcales F, Pennings P.
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Early Gravettian genomic data from Western Europe reveal population movements before the LGM. [PDF]

Sci Adv
Gelabert P, Sawyer S, Villalba-Mouco V, Cheronet O, Oberreiter V, Gárate D, Normand C, Straus LG, González Morales MR, Gutiérrez-Zugasti I, Cuenca-Solana D, Darricau J, de Lumley H, Tejero JM, Stahlschmidt M, Higham T, Giannì M, van der Sluis LG, Gómez-Montes C, Ibáñez-Herranz M, Hämmerle M, Zagorc B, Exler F, Brück F, Franz S, Tenorio Cano F, Stewardson K, Qiu L, Marín-Arroyo AB, Lucci M, Nava A, Genchi F, Coppola D, La Marca C, Coppa A, Reich D, Pinhasi R.   +36 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source