Results 211 to 220 of about 714,798 (302)

Genomic diversity and adaptive resistance mechanisms in <i>Pseudomonas aeruginosa</i> from bronchiectasis. [PDF]

mSystems
Xiao Y, Zhang J, Nie F, Peng T, Li P, Li K, Tao X, Wei D, Zheng F, Zhao R, Zhang W.   +10 more
europepmc   +1 more source

Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings

Advanced Materials, EarlyView.
Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed, Yu‐Hsuan Peng, Azra Atabay, Krishna Gupta, Toni Müller, Carolin Fischer, Ilka M. Hermes, Jens‐Uwe Sommer, Michael Lang, Elisha Krieg   +9 more
wiley   +1 more source

Whole-genome sequencing reveals genomic diversity and selection signatures for adaptation in South African Afrikaner and Bonsmara cattle. [PDF]

Front Genet
Alberts D, van Marle-Köster E, Joubert F, Berry DP.   +3 more
europepmc   +1 more source

Bioinspired, Mitochondria‐Targeted Single‐Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​

Advanced Materials, EarlyView.
A bioinspired nanozyme—triphenylphosphonium (TPP)‐dendritic mesoporous silica nanoparticle (DMSN)‐Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical‐sized bone defects rat ...
Yuwen Wang, Xinzhi Liang, Tiandi Xiong, Zheng Zhong, Ning Zhang, Boguang Yang, Dong Li, Qiongjiao Zeng, Xian Chen, Yiting Lei, Shangsi Chen, Chao Zheng, Liu Yang, Wei Huang, Rocky S. Tuan, Denghui Xie, Zhong Alan Li   +16 more
wiley   +1 more source

Characterization of genomic diversity and population structure of worldwide Duroc subpopulations and other pig breeds. [PDF]

Genet Sel Evol
Wen H, Blackburn HD, Mulim HA, Oliveira HR, Hermesch S, Chen CY, Holl J, Schinckel AP, Brito LF.   +8 more
europepmc   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Exploration of the genomic diversity of third-generation cephalosporin-resistant <i>Escherichia coli</i> in Australian clinical settings. [PDF]

Microb Genom
Maqbool M, Sherry NL, Kwong JC, Howden BP, Gorrie CL, Ingle DJ, The Controlling Superbugs Study Group.   +6 more
europepmc   +1 more source

The use of genomic coancestry matrices in the optimization of contributions for maintaining diversity at specific regions of the genome [PDF]

, 2014
Fernandez, Jesus, Gómez-Romano, Fernando, Pong-Wong, Ricardo, Villanueva, Beatriz, Woolliams, John   +4 more
core  

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

The genomic diversity of arthropod-specific viruses reinforces the continental distribution pattern of Aedes aegypti. [PDF]

Parasit Vectors
Briñez WD, Urrea DA, Muñoz M, Patiño LH, Ramírez JD.   +4 more
europepmc   +1 more source