Results 251 to 260 of about 714,798 (302)

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Analysis of the Dirigent Pan-Gene Family in 26 Diverse Inbred Lines Reveals Genomic Diversity in Maize. [PDF]

Genes (Basel)
Liu Z, Xue Y, Xie Y, Zhao Y, Yang W, Yang W, Wang F, Ren X.   +7 more
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Unraveling the intra-species genomic diversity of sweetpotato-infecting CRESS-DNA and RNA viruses in Burkina Faso using Oxford Nanopore sequencing. [PDF]

Front Microbiol
Name PE, Tibiri EB, Tiendrébéogo F, Sawadogo S, Djigma F, Traoré L, Eni AO, Pita JS.   +7 more
europepmc   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Genomic diversity, antimicrobial resistance and dissemination of <i>Serratia marcescens complex</i> in patients admitted to ICUs. [PDF]

Front Cell Infect Microbiol
Zhu W, Chen X, Shen H, Wei M, Yang C, Gu L.   +5 more
europepmc   +1 more source

Temporal Genomics Reveal a Century of Genomic Diversity Shifts Across a Biodiversity Hotspot Avian Assemblage. [PDF]

Genome Biol Evol
Manthey JD, Settlecowski AE, Meheretu Y, Behrends GJ, Bourgeois Y, Campillo LC, Boissinot S, Marks BD.   +7 more
europepmc   +1 more source

Expanding the genomic diversity of human anelloviruses. [PDF]

Virus Evol
Modha S, Hughes J, Orton RJ, Lytras S.
europepmc   +1 more source

Surveillance of genomic diversity and antimicrobial resistance in enterotoxigenic <i>Escherichia coli</i> in England, 2015-2023. [PDF]

J Med Microbiol
Grigoruta DG, Poh CJ, Rodwell EV, Crewdson A, Nair S, Jenkins C.   +5 more
europepmc   +1 more source

Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits. [PDF]

BMC Genomics
Wang J, Zhang Y, Yang C, Ju Z, Xiao Y, Jiang Q, Liu W, Wang X, Wei X, Gao Y, Zhao X, Wang L, Gao Y, Li J, Huang J.   +14 more
europepmc   +1 more source