Results 131 to 140 of about 4,164,752 (382)

DNA methylation in genomic imprinting

Mutation Research/Reviews in Mutation Research, 1997
As a reversible epigenetic modification which can affect gene expression, DNA methylation has been an attractive candidate for the biochemical mechanism of genomic imprinting. Many correlations in mice and humans link allele-specific DNA methylation to the allele-restricted RNA expression which is the hallmark of imprinted genes. Moreover, abnormal DNA
openaire   +3 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Optimizing a modified cetyltrimethylammonium bromide protocol for fungal DNA extraction: Insights from multilocus gene amplification

Open Life Sciences
Genomic DNA (gDNA) extraction is an important step in many molecular studies of fungal biology, and it is necessary to evaluate the efficiency, cost-effectiveness, and efficacy of different extraction methods to ensure successful amplification of the ...
Dar Gulam Jeelani, Nazir Ruqeya, Wani Shakil A., Farooq Saleem, Aziz Tariq, Albekairi Thamer H.   +5 more
doaj   +1 more source

Characterization of Celosia argentea Linn. germplasm using ISSR markers

Studia Universitatis Babeș-Bolyai. Biologia
Celosia argentea is an annual leafy vegetable popularly known for its dietary and medicinal values. Hence, it is important to preserve and further improve this vegetable to enhance its numerous benefits.
Odunayo Joseph OLAWUYI, Haneefah Lola MISBAHUDEEN, Oluwagbade Joseph ODIMAYO, Adedayo Omotayo FANEYE, Olumayowa Mary OLOWE, Akinlolu Olalekan AKANMU   +5 more
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

PCR-based Assay for Genome Integrity after Methyl Methanesulfonate Damage in Physcomitrella patens

Bio-Protocol, 2016
In plant cells, genomic DNA exists in three organelles: the nucleus, chloroplast, and mitochondrion. Genomic DNA can be damaged by endogenous and exogenous factors, but the damaged DNA can be repaired by DNA repair systems.
Masaki Odahara, Takayuki Inouye, Yoshiki Nishimura, Yasuhiko Sekine   +3 more
doaj   +1 more source

The Genome and Methylome of a Subsocial Small Carpenter Bee, Ceratina calcarata [PDF]

, 2016
Understanding the evolution of animal societies, considered to be a major transition in evolution, is a key topic in evolutionary biology. Recently, new gateways for understanding social evolution have opened up due to advances in genomics, allowing for ...
Glastad, Karl M., Hunt, Brendan G., Lawson, Sarah P., Rehan, Sandra M.   +3 more
core   +2 more sources

A computer program for aligning a cDNA sequence with a genomic DNA sequence.

Genome Research, 1998
We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors.
Liliana Florea, G. Hartzell, Zheng Zhang, G. Rubin, W. Miller   +4 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Whole genome amplification and real-time PCR in forensic casework

BMC Genomics, 2009
Background WGA (Whole Genome Amplification) in forensic genetics can eliminate the technical limitations arising from low amounts of genomic DNA (gDNA).
Asili Paola, Solla Gianluca, Ricci Omero, Gabriele Luciano, Marsala Patrizio, Zampatti Stefania, Martone Claudia, Pietrangeli Ilenia, Giardina Emiliano, Arcudi Giovanni, Spinella Aldo, Novelli Giuseppe   +11 more
doaj   +1 more source