Results 131 to 140 of about 1,136,601 (292)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Faculty Opinions recommendation of Synthetic biology. Genomically encoded analog memory with precise in vivo DNA writing in living cell populations.

, 2015
Joelle N. Pelletier, Maximilian C. C. J. C. Ebert   +1 more
openalex   +2 more sources

Mitochondrial H ₂ O ₂ release does not directly cause genomic DNA damage [PDF]

, 2023
Daan M. K. van Soest, Paulien E. Polderman, Wytze T. F. den Toom, Susan Zwakenberg, Sasha De Henau, Boudewijn Burgering, Tobias B. Dansen   +6 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders.

, 2021
James Peter Stewart, Jana Gazdova, Nikos Darzentas, Dörte Wren, Paula Proszek, Grazia Fazio, Simona Songia, Miguel Alcoceba, Maria Eugenia Sarasquete, Patrick Villarese, Michèle Y van der Klift, Kim C Heezen, Neil McCafferty, Karol Pal, Mark Catherwood, Chang Sik Kim, Shambhavi Srivastava, Leonie I Kroeze, Elizabeth Hodges, Kostas Stamatopoulos, Wolfram Klapper, Elisa Genuardi, Simone Ferrero, Michiel van den Brand, Giovanni Cazzaniga, Frederic Davi, Lesley-Ann Sutton, Ramon Garcia-Sanz, Patricia J T A Groenen, Elizabeth A Macintyre, Monika Brüggemann, Christiane Pott, Anton W Langerak, David Gonzalez,   +34 more
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Quantitative Analysis of DNA Double-Strand Breaks in Genomic DNA Using Standard Curve Method. [PDF]

J Clin Lab Anal
Guo L, Dai H, Li J, Li C, Huang Y, Xu K.
europepmc   +1 more source

A powerful and rapid approach to human genome scanning using small quantities of genomic DNA [PDF]

, 2001
Marian Beekman, Nico Lakenberg, Stacey S. Cherny, Peter de Knijff, Cornelis Kluft, Gert‐Jan B. van Ommen, George P. Vogler, Rune R. Frants, Dorret I. Boomsma, P. Eline Slagboom   +9 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source