Results 141 to 150 of about 3,454,386 (367)

Reconsidering the significance of genomic word frequency [PDF]

arXiv, 2006
We propose that the distribution of DNA words in genomic sequences can be primarily characterized by a double Pareto-lognormal distribution, which explains lognormal and power-law features found across all known genomes. Such a distribution may be the result of completely random sequence evolution by duplication processes.
arxiv  

The Genomic Complexity of Acanthamoeba castellanii Mitochondrial DNA [PDF]

, 1974
Hans J. Bohnert, Reinhold G. Herrmann
openalex   +1 more source

Universal linker and ligation procedures for construction of genomic DNA libraries enriched for microsatellites.

BioTechniques, 1999
Microsatellite loci are highly informative genetic markers useful for population genetic studies, linkage mapping and parentage determination. Methods to identify novel microsatellite loci commonly use subtractive hybridization to enrich small-insert ...
M. Hamilton, Elaine L. Pincus, A. Fiore, R. Fleischer   +3 more
semanticscholar   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Focused size selection of cell-free DNA samples for liquid biopsy applications that rely on next-generation sequencing

BioTechniques, 2019
Genomic analysis of circulating, cell-free DNA (cfDNA) is being used extensively for molecular diagnostics. Many approaches rely on the construction of cfDNA genomic libraries, targeted retrieval of specific genomic regions and analysis by next ...
Christopher K Raymond
doaj   +1 more source

Sequence of a genomic DNA clone for the small subunit of ribulose bis-phosphate carboxylase-oxygenase from tobacco [PDF]

, 1985
Barbara J. Mazur, Chok-Fun Chui
openalex   +1 more source

Extraction of genomic DNA from yeasts for PCR-based applications.

BioTechniques, 2011
We have developed a quick and low-cost genomic DNA extraction protocol from yeast cells for PCR-based applications. This method does not require any enzymes, hazardous chemicals, or extreme temperatures, and is especially powerful for simultaneous ...
M. Lõoke, Kersti Kristjuhan, A. Kristjuhan   +2 more
semanticscholar   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Human beta satellite DNA: genomic organization and sequence definition of a class of highly repetitive tandem DNA. [PDF]

, 1989
John S. Waye, H F Willard
openalex   +1 more source

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

Biology Open, 2012
Summary Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5′-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions ...
Ka C Lee, K. Padget, Hannah Curtis, I. Cowell, D. Moiani, Zbyslaw Sondka, Nicholas J. Morris, G. Jackson, S. Cockell, J. Tainer, C. Austin   +10 more
semanticscholar   +1 more source