Results 141 to 150 of about 4,164,752 (382)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Bio-Protocol, 2015 Ultraviolet (UV) irradiation induces helix distorting photolesions such as cyclobutane pyrimidine dimers (CPD) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PP) which threaten genomic integrity if unrepaired.
Jeong-Min Park, Tae-Hong Kang
doaj +1 more source
High-throughput on-chip DNA fragmentation [PDF]
, 2010 free microfluidic deoxyribonucleic acid (DNA) fragmentation chip that is based on hydrodynamic shearing. Genomic DNA has been reproducibly fragmented with 2-10 kbp fragment lengths by applying hydraulic pressure ΔP across micromachined constrictions in ...
Berg, A. van den +4 more
core +1 more source
Annotating the genome by DNA methylation
The International Journal of Developmental Biology, 2017 DNA methylation plays a prominent role in setting up and stabilizing the molecular design of gene regulation and by understanding this process one gains profound insight into the underlying biology of mammals. In this article, we trace the discoveries that provided the foundations of this field, starting with the mapping of methyl groups in the genome ...
Howard Cedar, Aharon Razin
openaire +4 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
A Review on Role of Bloom Filter on DNA Assembly
IEEE Access, 2019 The advancement of DNA assembly techniques has greatly boosted up the bioinformatics research and discovery. More precisely, DNA assembly has achieved tremendous popularity due to the ability to decode the hidden information in the DNA.
Sabuzima Nayak, Ripon Patgiri
doaj +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
The Genomic Complexity of Acanthamoeba castellanii Mitochondrial DNA [PDF]
, 1974 Hans J. Bohnert, Reinhold G. Herrmann
openalex +1 more source
PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA.
PCR methods and applications, 1991 T e c h n i c a l progress in the determination of DNA sequence has resulted in an enormous amount of DNA sequence data, with technical innovations such as the polymerase chain reaction (PCR) accelerating the rate of increase of this data.
Kenshi Hayashi
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source