Results 31 to 40 of about 4,164,752 (382)
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Nature Communications, 2018 Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose ...
Naiara Santana-Codina +10 more
doaj +1 more source
Optimization of high molecular weight DNA extraction methods in shrimp for a long-read sequencing platform [PDF]
PeerJ, 2020 Marine organisms are important to global food security as they are the largest source of animal proteins feeding mankind. Genomics-assisted aquaculture can increase yield while preserving the environment to ensure sufficient and sustainable production ...
Pacharaporn Angthong +11 more
doaj +2 more sources
Analysis of Archived Residual Newborn Screening Blood Spots After Whole Genome Amplification [PDF]
, 2015 Deidentified newborn screening bloodspot samples (NBS) represent a valuable potential resource for genomic research if impediments to whole exome sequencing of NBS deoxyribonucleic acid (DNA), including the small amount of genomic DNA in NBS material ...
Benstead-Hume, Graeme +7 more
core +3 more sources
DNA repair: Caretakers of the genome? [PDF]
Current Biology, 1997 Recent results show that the 8-oxoguanine DNA repair system is functionally conserved in bacteria and mammals. The bacterial system protects the genome from the mutagenic effects of oxidative stress; the role of the mammalian system is expected to be similar and defects in it may increase susceptibility to cancer.
openaire +3 more sources
The Role of NCOA4-Mediated Ferritinophagy in Health and Disease
Pharmaceuticals, 2018 Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin (“ferritinophagy„), the cytosolic iron storage complex.
Naiara Santana-Codina, Joseph D. Mancias
doaj +1 more source
An investigation into inter- and intragenomic variations of graphic genomic signatures [PDF]
, 2015 We provide, on an extensive dataset and using several different distances, confirmation of the hypothesis that CGR patterns are preserved along a genomic DNA sequence, and are different for DNA sequences originating from genomes of different species ...
Karamichalis, Rallis +3 more
core +3 more sources
Journal of Biological Chemistry, 2014 Background: Exosomes are small vesicles in the tumor microenvironment containing nucleic acids and proteins with the capacity to influence cell behavior. Results: Exosomes contain double-stranded genomic DNA.
C. Kahlert +10 more
semanticscholar +1 more source
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]
, 2012 Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Austin, Caroline +10 more
core +3 more sources
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).
BioTechniques, 2000 Preparation of mouse genomic DNA for PCR is costly and laborious, primarily because of the difficulty in physically separating DNA from other tissue components. This level of purification is unnecessary for many PCR applications.
G. Truett +5 more
semanticscholar +1 more source
Definitions, 2020 Human blood DAT promoter methylation NucleoMag Blood 200 μL Transl Psychiatry 2015; 5:e648 Wiers et al. Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism Automated isolation of genomic DNA ...
semanticscholar +1 more source