Results 41 to 50 of about 1,062,471 (320)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Scientific Papers Animal Science and Biotechnologies, 2023 The high-resolution melting analysis is a cost-effective and simple post-PCR technique that can be used for SNP genotyping. The objective of this study was to apply the high resolution melting analysis for detection of SNP polymorphism CAPN530 of bovine ...
Michal Gábor +3 more
doaj
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
DNA methylation profiling of genomic DNA isolated from urine in diabetic chronic kidney disease: A pilot study. [PDF]
PLoS ONE, 2018 To characterise the genomic DNA (gDNA) yield from urine and quality of derived methylation data generated from the widely used Illuminia Infinium MethylationEPIC (HM850K) platform and compare this with buffy coat samples.DNA methylation is the most ...
Ashani Lecamwasam +5 more
doaj +1 more source
Targeting Dna Methylation to the Genome
BioTechniques, 2014 Proving direct relationships between DNA alterations and phenotypes is challenging. For epigenetics researchers, linking DNA methylation with human disease is no exception. But Patrick Lo looks at how two researchers are developing new methods to try to trace the road from DNA methylation to human biology.
openaire +4 more sources
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women. [PDF]
PLoS ONE, 2013 Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia.We evaluated the association between pre-diagnostic leukocyte genomic DNA methylation level
Hongmei Nan +7 more
doaj +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Gut microbiome as a biomarker of cardiometabolic disorders
Annals of Agricultural and Environmental Medicine, 2017 Introduction and objective Cardiovascular diseases are the leading cause of death in Europe and worldwide. One of the most important risk factors for atherosclerosis are lipid metabolism disorders, in particular hipercholesterolaemia.
Anna Gózd-Barszczewska +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source