Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3 [PDF]
, 2010 double Holliday junction (dHJ) is a central intermediate of homologous recombination that can be processed to yield crossover or non-crossover recombination products. To preserve genomic integrity, cells possess mechanisms to avoid crossing over. We show
C Gaillard +37 more
core +2 more sources
Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting.
Blood, 2016 The spectrum of somatic alterations in hematologic malignancies includes substitutions, insertions/deletions (indels), copy number alterations (CNAs), and a wide range of gene fusions; no current clinically available single assay captures the different ...
Jié He +50 more
semanticscholar +1 more source
Clinical consequences of BRCA2 hypomorphism
npj Breast Cancer, 2021 The tumor suppressor FANCD1/BRCA2 is crucial for DNA homologous recombination repair (HRR). BRCA2 biallelic pathogenic variants result in a severe form of Fanconi anemia (FA) syndrome, whereas monoallelic pathogenic variants cause mainly hereditary ...
Laia Castells-Roca +17 more
doaj +1 more source
Joint profiling of DNA methylation and chromatin architecture in single cells. [PDF]
, 2019 We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the ...
AD Schmitt +31 more
core +1 more source
Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe [PDF]
, 1993 A modification of reverse chromosome painting was carried out using genomic DNA from tumor cells as a complex probe for chromosomal in situ suppression hybridization to normal metaphase chromsome spreads.
Cremer, Thomas +5 more
core +1 more source
Discovery of Double-Stranded Genomic DNA in Circulating Exosomes.
Cold Spring Harbor Symposia on Quantitative Biology, 2016 It is becoming increasingly clear that small vesicles released from cells (extracellular vesicles [EVs]) represent a heterogeneous population implicated in cell-to-cell communication. The classifications and nomenclature of EVs are evolving as enrichment
R. Kalluri, Valerie S. LeBleu
semanticscholar +1 more source
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features [PDF]
Bioinform., 2013 MOTIVATION Next-generation sequencing technologies generate millions of short sequence reads, which are usually aligned to a reference genome. In many applications, the key information required for downstream analysis is the number of reads mapping to ...
Yang Liao, G. Smyth, Wei Shi
semanticscholar +1 more source
Genomics: DNA and diasporas [PDF]
Nature, 2016 Fatimah L. C. Jackson weighs up a study on the cultural politics of genetic testing among African Americans.
openaire +2 more sources
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability [PDF]
, 2017 R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability.
Aguilera López, Andrés +5 more
core +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source