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Genomics, genetic epidemiology, and genomic medicine
Clinical Gastroenterology and Hepatology, 2005Medical science is on the threshold of unparalleled progress as a result of the advent of genomics and related disciplines. Human genomics, the study of structure, function, and interactions of all genes in the human genome, promises to improve the diagnosis, treatment, and prevention of disease.
Konstantinos N, Lazaridis +1 more
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Graph Modeling for Genomics and Epidemiology
2023The last decades have seen great leaps made in the development of RNA sequencing technologies, yielding lower cost and greater throughput of experiments, to the point where the scale of the data produced on a daily basis is staggering. While computational hardware is also continuously improving, famously (or perhaps infamously) described by Gordon ...
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Bridging the gap between molecular and genomic epidemiology in tuberculosis: inferring MIRU-VNTR patterns from genomic data [PDF]
Journal of Clinical Microbiology: The transition from MIRU-VNTR-based epidemiology studies in tuberculosis (TB) to genomic epidemiology has transformed how we track transmission. However, short-read sequencing is poor at analyzing repetitive regions such as the MIRU-VNTR loci.
Laura Pérez-Lago +2 more
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At the interfaces of epidemiology, genetics and genomics
Nature Reviews Genetics, 2001You come onto the court prepared for tennis but your partner seems to be ready for rugby. Neither of you is at all sure what it is that your opponent wants to play. The only recourse is to teach each other the rules of your own game and then decide whether you can collectively invent a new sport.
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Genomics and molecular epidemiology of Cryptosporidium species
Acta Tropica, 2018Cryptosporidium is one of the most widespread protozoan parasites that infects domestic and wild animals and is considered the second major cause of diarrhea and death in children after rotavirus. So far, around 20 distinct species are known to cause severe to moderate infections in humans, of which Cryptosporidium hominis and Cryptosporidium parvum ...
Asis, Khan +2 more
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Genomic Epidemiology of Clostridioides difficile
Infectious Disease Clinics of North AmericaClostridioides difficile is the most common cause of health care-associated infections in the United States. The persistence of C difficile as a significant cause of morbidity and mortality is a testament to significant gaps remaining in our understanding of how and where it spreads, and pathways leading to disease. Over the past decade, the revolution
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An epidemiological view of microbial genomic data
The Lancet Infectious Diseases, 2013Mark Achtman devised the acronym YATM for “yet another typing method” when assessing the huge growth in the number of approaches to classifying different microbe strains. This increase was triggered by both new technologies and by the tendency for new typing schemes to be developed for each new question. Achtman concluded that the contribution of these
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Human Genome Epidemiology: Reviewing the Stakes
International Journal of Health Services, 2008Social science analysis of developments associated with the “new genetics,” as the science moves from the laboratory into the policy arena, has focused primarily on the implications of numerous potential interventions and the introduction of data banks. The field continues to burgeon.
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A navigator for human genome epidemiology
Nature Genetics, 2008Wei, Yu +4 more
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Genomic Epidemiology of SARS-CoV-2 in Guangdong Province, China
Cell, 2020Jayna Raghwani +2 more
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